Cancer Stem Cells, a small population residing within the tumor bulk are inherently chemoresistant in nature and the major cause behind tumor relapse. Previously we have shown modulation in IGF-1R-Akt axis is associated with development of chemoresistance in ovarian cancer cells (Singh et. al., 2014). Currently I am trying to investigate the role of IGF-1R-Akt signaling in Cancer Stem Cell phenotype and function during acquirement of chemoresistance.
Senior Research Fellow
Ram Kumar Singh