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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 10 May 2021 Vol. No. 10; Issue No. 474

1. Navalkar A, Pandey S, Singh N, Patel K, Datta D, Mohanty B, Jadhav S, Chaudhari P, Maji S (2021). Direct evidence of cellular transformation by prion-like p53 amyloid infection. Journal of Cell Science.

2. Deogharkar A, Singh SV, Bharambe HS, Paul R, Moiyadi A, Goel A, Shetty P, Sridhar E, Gupta T, Jalali R, Goel N, Gadewal N, Muthukumar S, Shirsat NV (2021). Downregulation of ARID1B, a tumor-suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways. Human Molecular Genetics.

3. de Souza R, Mhatre S, Qayyumi B, Chitkara G, Madke T, Joshi M, Bharmal R, Asgaonkar DS, Lakhani P, Gupta S, Chaturvedi P, Dikshit R, Badwe R (2021). Clinical course and outcome of patients with COVID-19 in Mumbai City: an observational study. BMJ Open. 11(5): e042943.

4. Baumann BC, Zaghloul MS, Murthy V (2021). Adjuvant and neoadjuvant radiation therapy for locally advanced Bladder cancer. Clinical Oncology. 33(6): 391-399.

Site of the Week

The National Cancer Institute's (NCI) Visuals Online provides a range of photographs and illustrations that may help communicators of medical and public health convey meaning, describe concepts, and tell stories. Visuals Online currently provides public access to 3,681 images.

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Interesting Reads

Navlakha S, Morjaria S, Perez-Johnston R, Zhang A, Taur Y. Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning. BMC Infect Dis. 21(1):391.

Legends of Science
Rudolf Ludwig Carl Virchow Sardul Singh Guraya

Sardul Singh Guraya obtained his PhD (1959) and DSc (1971) from Panjab University, Chandigarh. He obtained his second PhD from International University Foundation, USA. He specialized in Cell biology and reproductive physiology. He determined the regulatory mechanisms involved and evolutionary significance of reproductive processes to different animal species. He highlighted structural and functional differences in animals and humans indicating future areas of research. He was Dean, Punjab Agricultural University, Ludhiana. He was member of Boards of WHO, UNESCO, ICMR, CSIR, UGC. He was awarded with SS Bhatnagar Prize (1973); Gold Medal at the Sixth International Congress of Animal Reproduction and Artificial Insemination, Paris; PAU Cash Prize, and Basanti Devi Amir Chand Prize of ICMR.

Andreas Vesalius Narendra Mohan Basu

Narendra Mohan Basu obtained his MSc (1913) from the University of Calcutta. He specialized in physiology and biochemistry. He did his research on strychnine and failing heart. He studied cobra venom and its action on heart. He discovered an accurate method on perfusions of frog’s heart. He made extensive studies on vitamin C, its relation to human fatigue, excretion, nature in green and ripe mangoes. He also studied its relation in blood coagulation and blood sugar curve. He studied the action of Ca, K ions and adrenaline group of alkaloids in fatigue of muscles. He was head, Physiology Department, Presidency College, Kolkatta. He was member, Physiological Society of India, Elected President, Physiology Section, Indian Science Congress (1939).

Do You Know?

In 2009, A technique was developed wherein single stem cells or single crypt structures from intestinal crypts can generate ‘organoids’ in vitro structures with the architecture of, and all differentiated cell types present in, organ structures.

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Cancer News
Restricting growth, spread of head and neck cancers

05 May 2021, ScienceDaily

Researchers have discovered a key molecule that allows cancer stem cells to bypass the body's natural immune defenses, spurring the growth and spread of head and neck squamous cell cancers...

Scientists discover how to trick cancer cells to consume toxic drugs

06 May 2021, EurekAlert

New research led by a team at Massachusetts General Hospital (MGH) points to a promising strategy to boost tumors' intake of cancer drugs, thereby increasing the effectiveness of chemotherapy treatments...

Aggressive brain tumors can mimic normal brain repair processes

06 May 2021, MedicalXpress

Using the pre-clinical mouse models, the researchers found that Pranlukast, a drug clinically approved for treating asthma in people, suppressed glioblastoma growth...

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