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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 12 April 2021 Vol. No. 10; Issue No. 470

1. Kulkarni PD, Damle ND, Hingorani L, Bhaskar VH, Ghante MR, Patil A, Gurjar M, Gota V (2021). Pharmacokinetics of solid lipid Boswellia serrata particles in healthy subjects. Drug Metabolism and Personalized Therapy

2. Dutta S, Bose K (2021). Remodelling structure-based drug design using machine learning. Emerging Topics in Life Sciences.

3. Gota V, Nookala M, Bonda A, Karanam A, Shriyan B, Kembhavi Y, Gurjar M, Patil A, Singh A, Goyal N, Gupta S (2021). Effect of body mass index on pharmacokinetics of paclitaxel in patients with early breast cancer. Cancer Medicine.

4. Chilukuri S, Murthy V (2021). Adjuvant radiation for prostate cancer: Too early to abandon? BJU International.

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Online Kaplan-Meier plotter can be used to assess the effect of the genes on cancer prognosis.

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Interesting Reads

Chen K, Wang Q, Li M, Guo H, Liu W, Wang F, Tian X, Yang Y. Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression. EBioMedicine. 2021.

Legends of Science
Rudolf Ludwig Carl Virchow M V Govindaswamy

M V Govindaswamy obtained his MBBS and DPM from England. He was an excellent medical scientist who specialized in psychiatry. Dr. Govindaswamy was the first psychiatrist to start psychosurgery in 1947. He was a great clinician and teacher who recognized the value of basic sciences as psychology, neurophysiology, genetics etc. He was the Superintendent, Mental Hospital (now National Institute of Mental Health and Neuroscience), Bangalore and also the Founder- Director, All India Institute of Mental Health (1954-59). Dr. Govindaswamy was the Member of National Advisory Council for Education of Mentally Handicapped. Dr. Govindaswamy was a Member/Fellow of Royal Society of Medicine (London) and Indian Medical Association and World Mental Health Federation.

Andreas Vesalius Ponani Narayana Ganapati

Ponani Narayana Ganapati obtained his DSc degree (1942) from the University of Madras. He specialized in protozoology – marine biology. His contributions include parasitic protozoa in marine worms and fishes, marine biology, biological oceanography, planktonology, marine pollution. He was the first to describe life histories of several new pathogenic sporozoans of the food fishes of India. He also carried out pioneering work on the systematics and ecology of littoral fauna at Vishakhapatnam and Kakinada and described several new species of Bryozoa, Mollusca, Polychaeta, Nematoda, Gastrotricha and Echinodermata. Dr. Ganapati was a teacher par excellence and a Professor Emeritus, Department of Zoology, Andhra University, Waltair. Dr. Ganapati was a Member of the Indian National Committee of Oceanographic Research (CSIR) and of Scientific Panel for Fisheries Research (ICAR). Dr. Ganapati received Curzon Prize (Maharajah of Travancore) (1942), Sir Dorabji Tata Gold Medal (1976).

Do You Know?

In 2004, Azacitidine, an inhibitor of DNA methylation and a pioneering epigenetic therapy, became the first drug to gain US Food and Drug Administration (FDA) approval for the treatment of myelodysplastic syndrome.

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Cancer News
Whole-Genome Sequencing Could Help Guide AML Treatment

06 April 2021, Natioanl Cancer Institute

For their study, the Washington University team developed a streamlined approach to sequencing the entire genome and analyzing the data from patient samples. By focusing the data analysis on the parts of the genome and types of genetic alterations already known to be important in AML and MDS...

Artificial Intelligence could 'crack the language of cancer and Alzheimer's'

08 April 2021, ScienceDaily

Powerful algorithms can 'predict' the biological language of cancer and neurodegenerative diseases like Alzheimer's, scientists have found. Big data produced during decades of research was fed into a computer language model to see if artificial intelligence can make more advanced discoveries than humans...

Cancer-killing virus therapy shows promise against inoperable skin cancers

09 April 2021, EurekAlert

The new study results showed that injections of experimental coxsackievirus drug V937, along with pembrolizumab, an immunotherapy drug known as pembro or Keytruda, was well tolerated...

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