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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 15 March 2021 Vol. No. 10; Issue No. 466

1. Kapoor J, Khushoo V, Garg A, Naim F, Bhatia N, Folbs B, Mehta P, Ahmed R, Agrawal N, Bhurani D, Mirgh SP (2021). An "impossible" harvest-GCSF-induced immune thrombocytopenia in an autologous stem cell transplant recipient with multiple myeloma. Bone Marrow Transplantation.

2. Bose K, Wagh A, Mishra V, Dutta S, Parui A, Puja R, Pandav-Mudrale S, Kulkarni S, Gai P, Sarin R (2021). Loss of GSK-3β mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype. International Journal of Biological Macromolecules.

Site of the Week

TissGDB is the tissue-specific gene annotation database in cancer, aiming to provide a resource or reference for cancer and the related disease studies in the context of tissue specificity.

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Interesting Reads

Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 184(5):1142-1155, 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Swarn Nityanand

Swarn Nityanand obtained her MD (Medicine) from King Georges Medical Colledge, Luknow (1960). She was a Research Fellow in Cardiology at Harvard Medical School (1958-59). Her research interests were development of new drugs for hyperlipidemias and related disorders. She established a battery of models for the critical role of experimental models simulating human disease. She demonstrated that simultaneous administration of adrenalin with the atherosclerotic agents greatly accelerated the speed and severity of atherogenic process. She jointly developed Gugulipid, a hypolipidemic agent from ethyl acetate extract of guggul, resin from Commiphora mukul. She also established the Clinical studies capability at CDRI. Centre was accredited by WHO for serum lipid analysis. Dr Swarn Nityanand was the recipient of Shree Dhanwantari Prize of INSA(1996) and the VASVIK Award.

Andreas Vesalius Sudha Gajanan Gangal

Sudha Gangal obtained her PhD under the guidance of Dr. Kamal Ranadive at Indian Cancer Research Centre (1963). She went to University of Michigan, Ann Arbor, for post-doctoral research on NIH fellowship. Her research there was on expression of H-2 antigens in mouse cell lines grown in vitro. She established Cancer Immunology Division at CRI. Her area of research included immunology of oral cancer. She established several oral cancer cell lines in vitro. She started Hybridoma Laboratory in 1980. She developed monocloncal antibodies to oral cancer cells and myloid leukemic cells. While she was Research Director, Wadia Children’s Hospital, Mumbai, she established Genetic Clinic, to boost the programme of mutation analysis for prenatal diagnosis of Thalassemia. She served as President of Indian Women Scientist’s Association (IWSA), Indian Immunology Society, and Indian Association of Cancer Research. She was awarded with Raja Ravi Sher Singh Memorial Award of ICMR (1974) and Ranbaxy Foundation Award (1981).

Do You Know?

In 1890, The transfer of blood sera from individuals who had recovered from an infectious disease to individuals with ongoing infection with the same pathogen was first described for tetanus and diphtheria; this approach is still used today as a first-line therapy against arising viral infections for which few or no treatments exist.

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Cancer News
New organelle involved in cancer metastasis

09 March 2021, ScienceDaily

Researchers discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation -- when liquid blobs of living materials merge into each other...

Imaging test could help guide breast cancer treatment decisions

11 March 2021, National Cancer Institute

The new imaging test may help pinpoint which patients have these resistant tumors by showing whether the estrogen receptors in tumors are active and responsive to estrogen...

State of the Art Digital Mammography Facility inaugurated at Tata Memorial Centre, Mumbai

11 March 2021, The Free Press Journal

On the occasion of International Women's Day, Chief Guest, Smt N. Ambika, Deputy Commissioner of Police, HQ, Mumbai, with Dr. R. A. Badwe, Director, Tata Memorial Centre, inaugurated a 'State of the Art' Contrast and 3D Digital Mammography equipment at Tata Memorial Hospital, Parel, Mumbai...

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