Advanced Centre for Treatment Research & Education in Cancer

Science Sparks @ ACTREC
16 August 2021	Vol. No. 10; Issue No. 488

Publications

1. Portner R, Bajaj A, Elumalai T, Huddart R, Murthy V, Nightinghale H, Patel K, Sargos P, Song Y, Hoskin P, Choudhury A (2021). A practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer. Clinical and Translational Radiation Oncology.

2. Otitoju AP, Longdet IY, Alemika TE, Gota VP (2021). Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells. Journal of the Egyptian National Cancer Institute. 33(1): 20.

3. Dholam K, Sharma M, Gurav S, Singh GP, Prabhash K (2021). Oral and dental health status in patients undergoing neo-adjuvant chemotherapy for locally advanced head and neck cancer. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.

4. Puranik AD, Rangarajan V, Dev ID, Jain Y, Purandare NC, Sahu A, Choudhary A, Gupta T, Chatterjee A, Moiyadi A, Shetty P, Sridhar E, Sahay A, Patil VM, Shah S, Agrawal A (2021). Brain FET PET tumor-to-white mater ratio to differentiate recurrence from ost-treatment changes in high-grade gliomas. Journal of Neuroimaging.

5. Nathany S, Chatterjee G, Ghai S, Moulik NR, Shetty D, Subramanian PG, Tembhare P, Gujral S, Dhamne C, Banavali S, Narula G, Patkar N. Mutational landscape of Juvenile Myelomonocytic Leukemia (JMML)-A real-world context. International Journal of Laboratory Hematology.

Thesis
Usha A. Patel (2021). Analysis of HPV, EGFR and Hypoxia Markers and their association with Clinical Outcome in Subjects with Locally Advanced Squamous Cell Carcinoma of Head and Neck. (HBNI: LIFE09201404005) (Guide: Dr. Manoj B. Mahimkar)

Site of the Week

The Genotype-Tissue Expression (GTEx) project is an ongoing effort to build a comprehensive public resource to study tissue-specific gene expression and regulation.

Interesting Reads

Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 12(1): 4860, 2021.

Legends of Science

Jyotish Chandra Gupta

Jyotish Chandra Gupta obtained his MD in pharmacology in 1908 from Calcutta. Dr. Gupta worked on elucidation and evaluation of indigenous drugs and their extracts, including several alkaloids, glucosides, and newly synthesized drugs. He carried out trials with many of the products and preparation. He recognized many of the tropical diseases and treated chronic diseases of the stomach, intestines, and liver. He made a remarkable contribution as a medical examiner and teacher of medicine. He was Director, School of Tropical Medicine, Calcutta. Dr. Gupta was a Member of the Indian Medical Association.

Nagarur Gopinath

Nagarur Gopinath obtained his MS Cardiothoracic in 1960 from the University of Madras. He specialized in cardiothoracic vascular surgery. He did pioneering work in surgery for rheumatic heart disease and implantation of cardiac pacemakers. He studied the microanatomy of the aortic valve and was instrumental in establishing human and animal valve bank at AIIMS. Dr. Gopinath was the recipient of Padma Shri Award in 1974, BC Roy Award in 1978. He was a fellow of National Academy of Medical Sciences, C Walton and Richard Lillehei Surgical Society, USA.

Do You Know?

In 2009, the discovery that sodium bisulfite converts unmethylated cytosines into uracil drove the development of many new DNA methylation detection and analysis techniques.

Cancer News

Radioactive marker enables imaging of iron-hungry cancer cells

10 August 2021, physicsWorld

Researchers at the University of California, San Francisco, have developed a way to assess the amount of available iron inside a cancer cell and therefore predict whether these new iron-targeting treatments might be effective on a particular patient’s tumour...

Deep learning model classifies brain tumors with single MRI scan

11 August 2021, ScienceDaily

A team of researchers have developed a deep learning model that is capable of classifying a brain tumor as one of six common types using a single 3D MRI scan, according to a new study...

Immunotherapy may be effective in certain patients with metastatic colorectal cancer

12 August 2021, Pharmacy Times

The study analyzed data from 95 patients with MSS metastatic colorectal cancer who received immune checkpoint inhibitor programmed cell-death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) targeted therapy when their disease became resistant to chemotherapy...