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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 16th May 2022 Vol. No. 11; Issue No. 526

1. Laskar S, Sinha S, Chatterjee A, Khanna N, Manjali JM, Puri A, Gulia A, Nayak P, Vora T, Chinnaswamy G, Prasad M, Bajpai J, Juvekar S, Desai S, Janu A, Rangarajan V, Purandare N, Shah S, Rekhi B, Jambhekar N, Muckaden M, Kurkure P (2022). Radiotherapy dose escalation in unresectable Ewing's sarcoma: Final results of a phase III randomized controlled trial. International Journal of Radiation Oncology,Biology,Physics.

2. Rao S, Sahay A, Epari S (2022). Paediatric type diffuse high grade gliomas in the WHO CNS5 classification: What the pathologist needs to know?. Indian Journal of Pathology & Microbiology 65(Suppl S1):50-8.

3. Desai S, Mishra R, Ahmad S, Hait S, Joshi A, Dutt A (2022). TMC-SNPdb 2.0: an ethnic-specific database of Indian germline variants. Database: The Journal of Biological Databases and Curation..

Site of the Week

Crystallography Open-access database consists of collection of crystal structures of organic, inorganic, metal-organics compounds and minerals.

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Interesting Reads

Qi C, Gong J, Li J, Liu D, Qin Y, Ge S, Zhang M, Peng Z, Zhou J, Cao Y, Zhang X, Lu Z, Lu M, Yuan J, Wang Z, Wang Y, Peng X, Gao H, Liu Z, Wang H, Yuan D, Xiao J, Ma H, Wang W, Li Z, Shen L. Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results. Nature Medicine.

Legends of Science
Siddhartha Roy Siddhartha Roy

Siddhartha Roy obtained his Ph.D. from the University of Delaware in 1981. He worked on protein folding and NMR studies of DNA. He explored the structural and energetic basis of regulation of transcription as well as the origin of specificity in protein-nucleic acids interaction. He first formulated the role of differential contact in the mechanism of transcription regulation and went on to demonstrate the validity of this theory in several gene regulatory circuits. Dr. Roy was conferred with the SS Bhatnagar Award in 1999; Meritorious Service Award by the Department of Health and Human Services, USA; Tata Innovation Fellowship by DBT and JC Bose Fellowship by DST.

Kalappagowda Muniyappa Kalappagowda Muniyappa

Kalappagowda Muniyappa obtained his Ph.D. from the University of Mysore in 1980. He made significant contributions to the research like chromosome synapsis, genetic recombination, telomerase dynamics, cell senescence, and genome stability. He uncovered a direct role for DNA damage response proteins in telomere length homeostasis, cell senescence, and cell cycle checkpoint control. He led the way in deciphering genetic recombination in TB bacilli, which provided important insights into the genetic exchange and lateral gene transfer mechanisms. He is the Fellow of the Indian Academy of Sciences, Bangalore (1994); National Academy of Sciences, Allahabad (1998). Dr. Muniyappa is the recipient of the SS Bhatnagar award in 1995, Eleanor Roosevelt award in 1995; Kempe Gowda award in 2007.

Upcoming Events
Molecular Biophysics of Membranes

05-10 June, 2022

At Tahoe, California, United States

EMBO Workshop — Protein termini: From mechanisms to biological impact

08-11 June, 2022

At Bergen, Norway

9th International Conference on Plasma Medicine (ICPM9)

27 June-01 July, 2022

At Utrecht, The Netherlands

Do You Know?

In 2010, A major study suggested that women who have completed ovarian cancer treatment may not need frequent CA125 blood tests to monitor for early signs of disease recurrence.

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Cancer News
Study identifies potential target for treating childhood blood cancer

10 May 2022, EurekAlert

Scientists have pinpointed a possible new target for treating patients with the blood cancer juvenile myelomonocytic leukaemia (JMML)...

Solid tumors use a type of T cell as a shield against immune attack

12 May 2022, ScienceDaily

Scientists have identified a subset of T cells that show up in great numbers in head and neck tumors, but not in similar tissues of the mouth inflamed by common ailments such as gum disease...

Gallstone disease shown to be strong predictor of pancreatic cancer

13 May 2022, MedicalXpress

PDAC is the most common pancreatic cancer, accounting for more than 90% of cases, and it is often fatal because it tends to be diagnosed in late stages...

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