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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 18th April 2022 Vol. No. 11; Issue No. 522
Publications

1. Guha A, Vijan A, Agarwal U, Goda JS, Mahajan A, Shetty N, Khattry N (2022). Imaging for plasma cell dyscrasias: What, when, and how? Frontiers in Oncology.

2. Chopra S, Goda J, Mittal P, Mulani J, Pant S, Pai V, Kannan S, Deodhar K, Krishnamurthy M, Menon S, Charnalia M, Shah S, Rangarajan V, Gota V, Naidu L, Sawant S, Thakkar P, Popat P, Ghosh J, Rath S, Gulia S, Engineer R, Mahantshetty U, Gupta S (2022). Concurrent chemoradiation and brachytherapy alone or in combination with nelfinavir in locally advanced cervical cancer (NELCER): study protocol for a phase III trial. BMJ Open.

3. Sudharsan MG, Venkatraman P (2022). A crystal form of PSMD10 Gankyrin with channels accessible to small molecules. Current Science. 122(6): 674-681.

4. Khan MA, Siddiqui MQ, Kuligina E, Varma AK (2022). Evaluation of conformational transitions of h-BRCA2 functional domain and unclassified variant Arg2502Cys using multimodal approach. International Journal of Biological Macromolecules.

Site of the Week

The CORUM database is a collection of experimentally verified mammalian protein complexes.

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Interesting Reads

Toya R, Saito T, Fukugawa Y, Matsuyama T, Matsumoto T, Shiraishi S, Murakami D, Orita Y, Hirai T, Oya N. Prevalence and risk factors of retro-styloid lymph node metastasis in oropharyngeal carcinoma. Ann Med. 54(1):436-441, 2022.

Legends of Science
Alok Kumar Datta Alok Kumar Datta

Alok Kumar Datta obtained his Ph.D. from Kolkata University in 1974. He was the first to establish that the adenosine kinase of purine auxotrophic parasites could be an exploitable chemotherapeutic target. His laboratory worked on cloning the enzyme from Leishmania donovani, delineating its active site, mechanical aspects of the reaction, and structural analysis. Dr. Datta is a recipient of the Professor IS Bhatia Memorial Award of the Society of Biological Chemists. He is a Fellow of the Indian Academy of Sciences, Bangalore; National Academy of Sciences, Allahabad.

Jayaraman Gowrishankar Jayaraman Gowrishankar

Jayaraman Gowrishankar received his Ph.D. from the University of Melbourne, Australia, in 1983. His contributions include the discovery of the operon and its exquisite osmotic regulation. His group developed and patented a generic process for salt-inducible overproduction of recombinant proteins in E coli. He was the recipient of the INSA medal for young scientist in 1986; CSIR young scientist award in 1987; SS Bhatnagar Prize in 1997; Padma Shri Award in 2013. Dr. Gowrishankar is the Fellow of the Indian Academy of Sciences, Bangalore; National Academy of Sciences, Allahabad.

Upcoming Events
2022 Summit on Cancer Health Disparities

29 April-01 May, 2022

At Grand Hyatt, Seattle, WA.

Nasopharyngeal Carcinoma and Beyond: Lessons and Learnings from Virus-Associated Carcinomas

08-13 May, 2022

At Rey Don Jaime Grand Hotel, Spain.

6th Theranostics World Congress

16-24 June, 2022

At RheinMain Congress Center Wiesbaden, Germany.

Do You Know?

In 1943, Pap test named for its inventor, George Papanicolaou, enabled doctors to detect and treat cervical cancers or pre-cancers before they spread.

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Cancer News
Tumors change their metabolism to spread more effectively

13 April 2022, EurekAlert

The discovery adds to a growing body of work showing that specific products of metabolism, called oncometabolites, can drive many aspects of cancer progression and metastasis...

Vitamin E can boost immunotherapy responses by reinvigorating dendritic cells

14 April 2022, MedicalXpress

The researchers demonstrated that vitamin E directly binds and blocks the activity of the SHP1 checkpoint protein in dendritic cells, which increases antigen presentation and primes T cells for an anti-tumor immune response...

New knowledge on lymphoid cell maturity could lead to more effective IBD therapies

15 April 2022, ScienceDaily

A research group has analyzed how certain immune cells known as innate lymphoid cells (ILCs) develop into mature cells that play a part in inflammatory bowel disease (IBD). The findings could pave the way for more effective treatments against IBD, a disease that causes considerable suffering and that is linked to an increased risk of colorectal cancer...

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