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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 1 March 2021 Vol. No. 10; Issue No. 464

1. Mittra I, Mishra GA, Dikshit RP, Gupta S, Kulkarni VY, Shaikh HKA, Shastri SS, Hawaldar R, Gupta S, Pramesh CS, Badwe RA (2021). Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years: prospective, cluster randomised controlled trial in Mumbai. British Medical Journal. 372: n256.

2. Shetty D, Talker E, Jain H, Talker J, Patkar N, Subramanian P, Jain H, Bonda A, Punatar S, Gokarn A, Bagal B, Sengar M, Khattry N (2021). Evaluation of cytogenetic response in CML patients with variant Philadelphia translocation. Asia Pacific Journal of Clinical Oncology.

3. Parghane RV, Bhandare M, Chaudhari V, Shrikhande SV, Ostwal V, Ramaswamy A, Talole S, Basu S (2021). Surgical feasibility, Determinants and overall efficacy assessment of neoadjuvant PRRT with 177Lu-DOTATATE for locally advanced unresectable gstroenteropancreatic neuroendocrine tumors. Journal of Nuclear Medicine.

4. Rajendra A, Jain H, Bonda VNA, Nayak L, Tembhare P, Shetty D, Thorat J, Jain H, Subramanian PG, Patkar N, Chatterjee G, Khattry N, Gokarn A, Punatar S, Mokal S, Bagal B, Sengar M (2021). Outcomes and prognostic factors in adolescents and young adults with ALL treated with a modified BFM-90 protocol. Blood Advances 9;5(5):1178-1193.

5. Barange M, Epari S, Gurav M, Shetty O, Sahay A, Shetty P, Goda J, Moyiadi A, Gupta T, Jalali R (2021). TERT promoter mutation in adult glioblastomas: It's correlation with other relevant molecular markers. Neurology India. 69:126-34

Pravin Vitthal Marathe (2021). Creation of novel photochangable fluorescent protein through directed evolution.(HBNI No.: LIFE09201304003) (Guide: Dibyendu Bhattacharyya).

Site of the Week

PolymiRTS (Polymorphism in microRNAs and their TargetSites) is a database of naturally occurring DNA variations in microRNA (miRNA) seed regions and miRNA target sites. MicroRNAs pair to the transcripts of protein-coding genes and cause translational repression or mRNA destabilization.

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Interesting Reads

Erten C, Houdjedj A, Kazan H. Ranking cancer drivers via betweenness-based outlier detection and random walks. BMC Bioinformatics. 22(1): 62, 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Satyavati Motiram Sirsat

Satyavati Sirsat obtained her PhD (1958) from University of Mumbai. Sirsat went on to study electron microscopy at the Chester Beatty Research Institute, London. She was associated with the Tata Memorial Hospital for Cancer. As a senior doctoral student there, she was involved when the Department of Pathology at Tata was developed by the government into an independent ‘Cancer Research Institute’. She worked in the fields of cancer research pathology, wound healing and regeneration, viruses and human cancer for more than 50 years. She was the first to establish an electron microscopy lab at Indian Cancer Research Centre, a first in India, which gave Indian researchers the first thorough insight into the detailed cellular structure and offered ways for disease diagnosis through the examination of molecules within organs. She did exhaustive study in fibre and tissue structures of human cancers. She pioneered studies to understand the dangers of oral pre-cancer due to excessive paan and tobacco chewing habits. She was the founder and further served as President of The Electron Microscope Society of India. Later she worked with Bharatiya Vidya Bhavan Ayurvedic Centre, for a project on the classification of cancer diseases, making use of her rich knowledge in Sanskrit.

Andreas Vesalius Roopa Bai Furdoonji

Roopa Bai Furdoonji was the first female anesthetist of the world. She was one of the few women to enroll in medical courses at Hyderabad medical college in 1885. She obtained her degree called ‘hakeem’ which was equivalent to that of a medical doctor. The chief surgeon of British residency and the Principal of Hyderabad medical school, Edward Lawrie, guided her to become a specialist in anesthesia. She got a diploma in chemistry and physics from University of Edinburgh, which was very useful for doctors who handled anesthetics. Furdoonji pursued a medical degree from John Hopkins University. She played a major role in introducing the use of chloroform as an anesthetic in India. Her contributions were invaluable due to her widespread knowledge about anesthesia, at both the Chloroform Commissions held in 1888 and 1891.

Do You Know?

In 1967, The first licensed mumps vaccine was developed by Maurice Hilleman at Merck and based on a virus sample isolated from his daughter.

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Cancer News
3D Biopsies enable a better understanding of brain tumors

22 February 2021, Technology Networks

The images allow the tumor to be differentiated into two areas, the tumor tissue properly speaking, and the stroma, which gives support to the tumor, in which there are different immunological microenvironments. "Immune cells like microglia and macrophages are seen in both areas, but they are shaped by different subpopulations…

High energy radiotherapy could 'paint' tumors to avoid harming healthy tissue

23 February 2021, ScienceDaily

Researchers used a magnetic lens to focus a Very High Electron Energy (VHEE) beam to a zone of a few millimetres. Concentrating the radiation into a small volume of high dose will enable it to be rapidly scanned across a tumour, while controlling its intensity...

Breast examination as good as mammography to detect cancer: Study

25 February 2021, Times of India

Laying to rest a long running debate in oncology, a 20-year study from Tata Memorial Hospital in Parel has proved that clinical breast examination is as effective as mammography to check for breast cancer...

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