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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 20th December 2021 Vol. No. 10; Issue No. 505

1. Dev ID, Puranik AD, Rangarajan V, Gupta T, Purandare NC, Agrawal A, Shah S (2022). Radiation-induced meningioma in a case of medulloblastoma treated 11 Years ago-detected on 68Ga-DOTANOC PET/CT. Clinical Nuclear Medicine. 47(1):e108-e110.

2. Sandbhor P, Goda J, Mohanty B, Chaudhari P, Dutt S, Banerjee R (2021). Non-invasive transferrin targeted nanovesicles sensitize resistant glioblastoma multiforme tumors and improve survival in orthotopic mouse models. Nanoscale.

3. Chaubal R, Gupta S. (2021). The true human cost of the Novel Coronavirus 2019 (COVID-19) pandemic. Indian Journal of Medical and Paediatric Oncology.

4. Natu A, Singh A, Gupta S.(2021) Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities. World Journal of Hepatology. 13(11):1568-1583.

Site of the Week

SIM - Alignment Tool for protein sequences is a program which finds a user-defined number of best non-intersecting alignments between two protein sequences or within a sequence.

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Interesting Reads

Herdeis, L., Gerlach, D., McConnell, D. B., & Kessler, D. (2021). Stopping the beating heart of cancer: KRAS reviewed. Current opinion in structural biology, 71, 136–147.

Legends of Science
Gopalasamudram Narayana Ramachandran Gopalasamudram Narayana Ramachandran

Gopalasamundram Narayana Ramachandran obtained his doctorate from the University of Cambridge, the UK, in 1949. His specialization was in Molecular Biophysics. His main contribution was the theory of the molecular structure of biopolymers concerning their biological activities. His work was the turning point in the evolution of the theory of biopolymer conformation, which applies in almost all branches of biochemistry and molecular biology. His work was the starting point for developing CAT scan techniques in radiography and later MRI. Dr. Ramachandran was conferred with S S Bhatnagar Prize in 1961; J C Bose award in 1976. He was an honorary member of the American Society of Biological Chemists and the American Academy of Arts and Sciences.

Bagepally S Narasinga Rao Bagepally S Narasinga Rao

Bagepally S Narasinga Rao obtained his Ph.D. from the University of Mysore, Mysore, in 1955. His significant contribution was the etiology of protein-calorie malnutrition in India - the role of fat deficiency; analysis of the nutritive value of Indian foods by analytical tools; RDA of energy, proteins, and some minerals for Indians; the role of restricted dietary absorption of iron deficiency anemia. Dr. Rao was the Director of the National Institute of Nutrition, Hyderabad and the President of the Nutrition Society of India. He served on many National committees like ICMR, DST, ICAR, Planning Commission, PM's National Nutrition Mission, and many international committees like FAO and WHO.

Do You Know?

In 2010, FDA approved sipuleucel-T, a cancer treatment vaccine that is made using a patient's own immune system cells (dendritic cells), for the treatment of metastatic prostate cancer that no longer responds to hormonal therapy.

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Cancer News
New research identifies potential approach to mitigate CAR T-cell therapy toxicity

15 December 2021, MedicalXpress

Interferon gamma (IFNγ) is a cytokine produced by CAR T cells that initiates the cellular events that lead to cytokine release syndrome, but its contribution to the antitumor effects of CAR T-cell therapy remained unclear...

Immunotherapy combination most effective as initial treatment for BRAF+ melanoma

17 December 2021, National Cancer Institute

The NCI-sponsored clinical trial, called DREAMseq, included people with metastatic melanoma whose tumors had a specific mutation in the BRAF gene, called V600...

Research breakthrough could see HIV drugs used to treat lowgrade brain tumors

17 December 2021, ScienceDaily

Drugs developed to treat AIDS and HIV could offer hope to patients diagnosed with the most common form of primary brain tumor. The breakthrough is significant because, if further research is conclusive, the anti-retroviral drugs could be prescribed for patients diagnosed with meningioma and acoustic neuroma brain tumors (also known as schwannoma)...

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