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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 20 September 2021 Vol. No. 10; Issue No. 493

1. Paradkar P, Juvekar A, Barkume M, Amonkar A, Joshi J, Soman G, Vaidya A (2021). In vitro and in vivo evaluation of a standardized haridra (Curcuma longa Linn) formulation in cervical cancer. Journal of Ayurveda and Integrative Medicine.

2. Gardi N, Ketkar M, McKinnon R, Pandol S, Dutt S, Barreto S (2021). Down-regulation of metabolic pathways could offset the poor prognosis conferred by co-existent diabetes mellitus in pancreatic (head) adenocarcinoma. ANZ Journal of Surgery.

3. Sureshbabu SK, Godbole JH, Vaibhaw A, Chiplunkar SV (2021). Immunosuppressive microenvironment in oral cancer: Implications for cancer immunotherapy. Exploration of Immunology. 1:166-198.

4. Madhok A, Bhatt S, Philip C, Sureshbabu SK, Chiplunkar SV, Galande S. Transcriptome Signature of Vγ9Vδ2 T Cells Treated With Phosphoantigens and Notch Inhibitor Reveals Interplay Between TCR and Notch Signaling Pathways. Frontiers in Immunology. 12: 660361.

5. Yadav S, Pant D, Samaiya A, Kalra N, Gupta S, Shukla S (2021). ERK1/2-EGR1-SRSF10 axis mediated alternative splicing plays a critical role in head and neck cancer. Frontiers in Cell and Developmental Biology. 9:713661.

Site of the Week

The DrugAge database contains an extensive compilation of drugs, compounds and supplements (including natural products and nutraceuticals) with anti-ageing properties that extend longevity in model organisms.

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Interesting Reads

Mangal N, Erridge S, Habib N, Sadanandam A, Reebye V, Sodergren MH. Cannabinoids in the landscape of cancer. J Cancer Res Clin Oncol. 147(9): 2507-2534, 2021.

Legends of Science
Deepak Gaur Tarit Kumar Ghosh

Tarit Kumar Ghosh obtained his MD degree from University of Kolkata in 1944. His area of specialization was Neurology. Dr. Ghosh made an extensive study on epilepsy. As a National investigator designated by ICMR, he analyzed information from 500 epileptic patients and conducted a follow-up of over 17000 patients to highlight the adverse effect of delayed treatment, and insufficient medication. He was the first, to observe increased arteriolar dilation in epidemic dropsy and sleep vasoconstriction in congestive cardiac failure. He was the Director, Department of Neurology, Institute of Post Graduate Medical Education and Research, Chandigarh. He was a fellow of International Medical Sciences Association.

Mangalore Gopal Kini Mangalore Gopal Kini

Mangalore Gopal Kini obtained his Medical Degree from Madras Medical College in 1919. He specialized in Orthopedic Surgery and Anesthetic techniques. He was appointed as a Medical Superintendent of Government Stanley Hospital, Madras. He was the head of the team sent by the government to Car Nicobar to provide medical relief during the polio-endemic. Dr. Kini was a Fellow of the Royal Society of Edinburgh and American College of Surgeons. He was the Founder Member of the Association of Surgeons of India.

Do You Know?

In 1958, NCI researchers Emil Frei and James Holland and their colleagues pioneered the use of combination chemotherapy, in which multiple drugs with different mechanisms of action are used together to treat cancer.

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Cancer News
Engineers grow pancreatic 'organoids' that mimic the real thing

13 September 2021, ScienceDaily

Engineers developed a way to grow tiny replicas of the pancreas, using either healthy or cancerous pancreatic cells. Their models could help researchers develop and test potential drugs for pancreatic cancer...

Quitting smoking improves survival in people with lung cancer

14 September 2021, National Cancer Institute

Quitting smoking after a diagnosis of early-stage lung cancer may help people live longer, according to a new study. The study, which included more than 500 patients in Russia, also found that quitting smoking could delay a return of the cancer or worsening of the disease...

Improving leukemia therapy with targeted treatment approaches

16 September 2021, EurekAlert

The research team focuses on the MAPK signaling pathway, which is involved in the development of several cancers, and is controlled by JAK2 in myeloproliferative neoplasms. “We have found in previous studies that this signaling pathway remains active despite JAK2 inhibition, and continues to stimulate hematopoiesis...

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