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Science Sparks @ ACTREC
Date Image 21 June 2021 Vol. No. 10; Issue No. 480

1. Swamidas J, Pradhan S, Chopra S, Panda S, Gupta Y, Sood S, Mohanty S, Jain J, Joshi K, Phurailatpam R, Gurram L, Mahantshetty U, Agarwal J (2021). Development and clinical validation of Knowledge-based planning for Volumetric Modulated Arc Therapy of cervical cancer including pelvic and para aortic fields. Physics and Imaging in Radiation Oncology. 18: 61-67.

2. Dholam K, Singh G, Sathaye N, Gurav S, Shinde A (2021). Two-piece oral facial prothesis retained with magnets for a complex maxillary facial defect: A clinical report. The Journal of Prosthetic Dentistry.

3. Mahantshetty U, Gurram L, Bushra S, Ghadi Y, Dheera A, Paul J, Hande V, Chopra S, Ghosh J, Shylasree T S, Popat P, Sable N, Maheswari A, Gupta S (2021). Single application multi-fractionated image guided adaptive High Dose Rate Brachytherapy for Cervical Cancer- Dosimetric & Clinical Outcomes. International Journal of Radiation Oncology Biology and Physics.

4. Chaudhary N, Choudhary BS, Shah SG, Khapare N, Dwivedi N, Gaikwad A, Joshi N, Raichanna J, Basu S, Gurjar M, Smitha PK, Saklani A, Gera P, Ramadwar M, Patil P, Thorat R, Gota V, Dhar SK, Gupta S, Das M, Dalal SN (2021). Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. International Journal of Cancer.

Site of the Week

The Cell Image Library is a freely accessible, easy-to-search, public repository of reviewed and annotated images, videos, and animations of cells from a variety of organisms, showcasing cell architecture, intracellular functionalities, and both normal and abnormal processes.

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Interesting Reads

Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M (2021). Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature.

Legends of Science
Rudolf Ludwig Carl Virchow Bhabatarak Bhattacharyya

Bhabatarak Bhattacharyya obtained his PhD in Biochemistry from Kolkata University, Kolkata and obtained his postdoctoral training at National Institute of Health, Maryland. He later joined Bose Institute, Kolkata in 1978. His topic of research was colchicine-tubulin interaction. He elucidated the effect of the carbonyl group on the side chain of B-ring in the irreversible binding of colchicine. He demonstrated the fluorescence of colchicine-tubulin bind which is reported to have offered an alternative to radio-labeled colchicine in pharmacological assays and made the study of the kinetics of colchicine binding easier. His studies on mechanism of chaperone-like activity of tubulin and microtubule associated protein were significant in the design of lead compounds and new drugs for the treatment of cancer. Dr. Bhattacharya was the recipient of BC Guha Memorial Award, P S Sharma Memorial Award, and Shanti Swarup Bhatnagar Award (1988). He was the elected fellow of Indian Academy of Science, National Academy of Sciences and, The World Academy of Sciences.

Andreas Vesalius Mukund Lal Bhatia

Mukund Lal Bhatia obtained his PhD (1937) from Punjab University, Chandigarh, with specialization in Zoology and Entomology. He worked on morphology, functional morphology of Indian and foreign leaches. He was the Dean, University of Delhi, Delhi and Honorary Professor, Biosciences at Himachal Pradesh University, Shimla. Dr. Bhatia was President (1956) of Indian Science Congress and was a Member of Asiatic Society, and Zoological Society of India. He was a Fellow of Zoological Society of London.

Do You Know?

In 2000, a study reported germline loss-of-function mutations in the gene encoding a subunit of succinate dehydrogenase (SDH, also known as mitochondrial complex II) in patients with hereditary paraganglioma.

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Cancer News
Targeted drug found effective in thwarting pancreatic tumors

14 June 2021, EurekAlert

The researchers discovered a link between hyperactivation of the CDK protein and mutant KRAS addiction, and exploited this link preclinically to counter mutant KRAS-driven pancreatic cancer, warranting clinical investigation in patients afflicted with this deadly disease...

Genetically engineered nanoparticle delivers dexamethasone directly to inflamed lungs

16 June 2021, ScienceDaily

Nanoengineers have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue...

Most cancer cells grown in a dish have little in common with cancer cells in people

17 June 2021, MedicalXpress

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources...

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