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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 24 May 2021 Vol. No. 10; Issue No. 476

1. Gunatilake M,Ramchandra SG, Ingle A, Baumans V (2020). An overview on history of laboratory animal science in Asian countries. Journal of Laboratoty Animal Science. 6(2): 14-18.

2. Thorat R, Ingle A (2020). Breeding performance with special reference to pre-weaning mortality of C57BL/6 and B6D2F1 hybrid strain of mice maintained at ACTREC Animal Facility. Journal of Laboratoty Animal Science. 6(2): 19-23.

3. Singh G, Bendale K, Talwelkar S, Pawade S, Gera P, Patil A, Chavan P, Subramanian S, Chaudhari P (2020). Establishment of an orthotopic syngeneic rat model of hepatocellular carcinoma and its validation with microPET-CT imaging. Integrative Cancer Science and Therapeutics. 7: 1-5.

4. Rajendra A, Gokarn A, Mirgh S, Ravind R, Singh A, Goli VB, Punatar S, Chichra A, Tembhare P, Patkar N, Bhat V, Chavan P, Trivedi B, Joshi A, Khattry N (2021). SARS-CoV2 Infection in Hematopoietic Stem Cell Transplant recipients: A Case Series from a Tertiary Cancer Centre in India. Indian Journal of Hematology and Blood Tansfusion.

5. Butle A, Joshi A, Noronha V, Prabhash K, Dutt A (2021). Weekly osimertinib dosing prevents EGFR mutant tumor cells destined to home mouse lungs. Translational Oncology. 14(8):101111.

6. Subedi Ranjeeta, Budukh Atul, Chapagain Sandhya, Gyanwali Pradip, Gyawali Bishal, Khadka Kopila, Thakur Chanda, Dahal Uma, Dikshit Rajesh, Kumar Jha Anjani, Dhimal Meghnath (2021) Differences in cancer incidence and pattern between urban and rural Nepal: one-year experience from two population-based cancer registries. Ecancermedicalscience. 15: 1229.

7. Kumari N, Mathe VL, Krishna CM, Dongre PM (2021). BSA-drug-ZnO-PEI conjugates interaction with glycans of gp60 endothelial cell receptor protein for targeted drug delivery: a comprehensive spectroscopic study. Journal of Biomolecular and Structural Dynamics.

Site of the Week

The Expression Atlas provides information on gene expression patterns under different biological conditions.

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Interesting Reads

Almangush A, Bello IO, Heikkinen I, Hagström J, Haglund C, Kowalski LP, Nieminen P, Coletta RD, Mäkitie AA, Salo T, Leivo I. Stromal categorization in early oral tongue cancer. Virchows Arch. 478(5): 925-932, 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Sibte Hassan Zaidi

Sibte Zaidi obtained his Bachelor of Medicine and surgery (1945) from King George’s Medical College, Lucknow. Later he obtained his PhD from University of London. He was Head, Division of Experimental Medicine at Central Drug Research Institute, Lucknow. His specialization was mechanisms that underlie peptic ulcer, atherosclerosis, vasospasm, eosinophilia. He demonstrated the requirement of a mucus barrier in the prevention of peptic ulcer disease. He established research infrastructure at Indian Institute of Chemical Biology, Kolkata. He studied industrial toxins and the mechanism of pulmonary fibrosis due to exposure to toxins like asbestos, silica, wood dust, bagasse. Dr Zaidi was awarded Shanti Swaroop Bhatnagar Award (1963), Padma Shree (1977). He was awarded the William Yant award for lifetime achievements and contributions to industrial toxicology by American Industrial Hygiene Association.

Andreas Vesalius Harcharan Daas Tandon

Harcharan Daas Tandon obtained his PhD (1955) from Agra University and FRC Pathology from London. His main contributions are the discovery of, the first known human outbreak of liver disease caused by Aflatoxicosis, Evidence of diffuse parenchymal disease in non-supportive amoebic hepatitis, The presence of grade III and IV changes in pulmuno hypertension accompanying congenital heart disease, Description of diffuse intimal thickening of aorta as a variant of human atherosclerotic lesion. Dr. Tandon was the recipient of the Dr BC Roy Memorial Award (1980). He was Consultant to WHO on Medical Education, Member, WHO Task Force on Environmental Health Criteria for Mycotoxins. He was President, National Board of Examinations.

Do You Know?

In 2015, A study of colorectal cancer genomics puts forward a model of tumour evolution whereby tumour growth is predominantly driven by an early, mutational ‘Big Bang’ which produces numerous clones, none of which are subject to stringent selection.

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Cancer News
Cells from the center of tumors most likely to spread around the body

17 May 2021, ScienceDaily

Cells from different parts of kidney tumors behave differently, and surprisingly, cells within the center of a tumor are the most aggressive and have the highest chance of spreading around the body...

Tumor marker may help overcome endocrine treatment-resistant breast cancer

19 May 2021, MedicalXpress

The research offers a new approach to selecting patients for therapy that targets HER2, a protein that promotes the growth of cancer cells, to help avoid disease relapse or progression of endocrine-sensitive disease.

Immunotherapy combination shows benefit for patients with advanced melanoma

20 May 2021, EurekAlert

The trial, known as the RELATIVITY-047 study, compared the effectiveness of the drug nivolumab, an immune checkpoint inhibitor, by itself against a combination of the LAG-3 blocking antibody relatlimab and nivolumab given as a fixed-dose...

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