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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 29 March 2021 Vol. No. 10; Issue No. 468

1. Nair NS, Gupta S, Ghosh J, Desai S, Parmar V, Shet T, Chitkara G, Siddique S, Badwe RA (2021). Access to HER2-targeted therapy at a tertiary care center in India: An evolution. Indian Journal of Cancer.

2. Qureshi SS, Kazi M, Noronha J, Smriti V, Basu S, Shah S, Talole S (2021). Factors Influencing Cervical Lymph Node Metastasis in Pediatric Differentiated Thyroid Cancers. Indian Journal of Surgical Oncology.

3. Ashar S, Lipsa A, Khan N, Sarin R (2021). High cumulative risk of colorectal cancers and desmoid tumours and fibromatosis in South Asian APC mutation carriers. Journal of Medical Genetics.

4. Wadasadawala T, Sen S, Watekar R, Rane P, Sarin R, Gupta S, Parmar V, Kannan S, Mohanty SK (2021). Economic Distress of Breast Cancer Patients Seeking Treatment at a Tertiary Cancer Center in Mumbai during COVID-19 Pandemic: A Cohort Study. Asian Pacific Journal Cancer Prevention. 22(3):793-800.

5. D'Cruz A, Dhar H, Vaish H, Vaish R, Hawaldar R, Gupta S, Pantvaidya G, Chaukar D, Chaturvedi P, Pai P, Deshmukh A, Kane S, Nair D, Nair S, Ghosh-Laskar S, Agarwal J (2021). Depth of invasion in early oral cancers- is it an independent prognostic factor? European Journal of Surgical Oncology.

6. Joshi A, Mishra R, Desai S, Chandrani P, Kore H, Sunder R, Hait S, Iyer P, Trivedi V, Choughule A, Noronha V, Joshi A, Patil V, Menon N, Kumar R, Prabhash K, Dutt A (2021). Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations. Oncotarget. 12: 578-588.

Site of the Week

The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the data and results from studies that have investigated the interaction of genotype and phenotype in Humans.

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Interesting Reads

Sepich-Poore G, Zitvogel L, Straussman R, Hasty J, Wargo J. The microbiome and human cancer. Science. 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Charusita Chakravarty

Charusita Chakravarty graduated from Delhi University with a gold medal obtained her PhD, at Cambridge University, UK, under the guidance of David Clary. Her research was on the spectra and dynamics of Ar–OH, an open shell system that involved a lot of nuances. She completed her post-Doctoral at the University of California, under Horia Metiu. She returned to India (1994), later she joined IIT Delhi (1994). Her research interest were theoretical chemistry and chemical physics, the structure and dynamics of Liquids, water and hydration, nucleation and self-assembly. She also worked on atomic and molecular clusters. Her major work was on the application of path integral Monte Carlo simulation to unravel quantum mechanical effects in the properties of atomic and molecular clusters. She was awarded with B.M. Birla Science Award (1999), Shanti Swarup Bhatnagar Award for Science and Technology (2009).

Andreas Vesalius Asima Chatterjee

Asima Chatterjee obtained her DSc (1944) from the University of Calcutta. Her specialization was in Natural Products Chemistry and Reaction Mechanism. Her significant contribution in research areas were in Indole, isoquinoline, steroid alkaloids, terpenoids, polyphenolics and reaction mechanism. The novel antiepileptic drug, Marsilin and antimalarial drug, Ayush-64 are her major conributions. She was Dean, Faculty of Science, University of Kolkata, Project Coordinator, Centre of Advanced Study on Natural Products (UGC Progamme). She was member, Sigma Xi (USA), IACS, Chemical Society (London). She was the recipient of Nagarjuna Gold Medal (1940), Watumul Fellowship (1948-49), USA, Shanti Swarup Bhatnagar Award (1961), Padma Bhushan (1995).

Do You Know?

In 1931, Otto Heinrich Warburg received the Nobel Prize in Physiology for his work on aerobic and anaerobic metabolic processes in cells.

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Cancer News
Starving tumors by blocking glutamine uptake

22 March 2021, ScienceDaily

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a drug candidate that blocks the uptake of glutamine, a key food source for many tumors, and slows the growth of melanoma...

Improving cancer immunotherapy by inhibiting an enzyme’s activity

25 March 2021, Genetic Engineering and Biotechnology News

By removing the KDM4A gene in the mouse models, the researchers observed a significant decrease in squamous cell carcinomas and less metastasis of cancer to the lymph nodes...

Engineered immune cells deliver anticancer signal, prevent cancer from spreading

25 March 2021, National Institute of Health

Scientists have genetically engineered immune cells, called myeloid cells, to precisely deliver an anticancer signal to organs where cancer may spread...

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