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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 29th November 2021 Vol. No. 10; Issue No. 503

1. Raghavan R, Koyande N, Beher R, Chetlangia N, Ramadwar M, Pawade S, Thorat R, Hengel J, Sklyarova T, Roy F, Dalal SN.(2022) Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APC min mice. Biochemical and Biophysical Research Communications. 58: 14-19.

2. Sthanam L, Roy T, Patwardhan S, Shukla A, Sharma S, Shinde P, Kale H, Shekar P, Kondabagil K, Sen S. (2021).MMP modulated differentiation of mouse embryonic stem cells on engineered cell derived matrices. Biomaterial

3. Shirsat A, Pashilkar S, Chavan A, Kalra D, Gota V, Joshi A, Krishnamurthy M.(2021) Effect of the pandemic on quality-of-life data collection in prostate cancer patients. ClinicoEconomics and Outcomes Research. 13:937-941.

4. Das L, Shekhar S, Chandrani P, Varma AK. (2021) In silico structural analysis of secretory clusterin to assess pathogenicity of mutations identified in the evolutionarily conserved regions. Journal of Biomolecular Structure & Dynamics.

5. Sanapalli B, Yele V, Sigalapalli D, Gadewal N, Shaik A, Bhandare R, Annadurai S, Karri VVSR. (2021) Forging of nicotine for the effective management of diabetic wounds: A hybrid of scaffold hopping and molecular dynamics simulation approaches. Arabian Journal of Chemistry.

6. Gupta T, Maheshwari G, Gudi S, Chatterjee A, Phurailatpam R, Prabhash K, Budrukkar A, Ghosh-Laskar S, Agarwal P.(2021) Radiation necrosis of the bone, cartilage or cervical soft-tissues following definitive high-precision radio(chemo)therapy for head-neck cancer: uncommon and under-reported phenomenon. Journal of Laryngology and Otology.

7. Punatar S, Gokarn A, Nayak L, Bonda A, Mirgh S, Chichra A, Singh M, D'silva S, Khattry N. Human leukocyte antigen (HLA) alleles as predictive factors for benefit from lenalidomide in acute myeloid leukemia (AML). American Journal of Blood Research. 11(5):564-570.

8. Gupta S.(2021) What fascinates me in science... Indian Journal of Medical and Paediatric Oncology.

Site of the Week

The ECMDB (E.coli Metabolome Database) is an expertly curated database containing extensive metabolomic data and metabolic pathway diagrams about Escherichia coli (strain K12, MG1655).

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Interesting Reads

Balian A, Hernandez FJ. Nucleases as molecular targets for cancer diagnosis. Biomark Res. 9(1): 86.

Legends of Science
Thitapally Joseph Job Thitapally Joseph Job

Thitapally, Joseph Job obtained his DSc from the University of Madras in 1941. He specialized in oceanography, pisciculture, and fisheries technology. He systemized a unique scheme of 'Public health fish farming.' He estimated the efficiency of larvicidal and cyclopsidal fishes in the control of 'water-borne' diseases. He also worked on water-manuring and the culture of aquatic and semi-aquatic vegetables, which helped to utilize all cultivable waters for food production. Dr. Job was Assistant Regional Fisheries Officer for Asia and the Far East, FAO, United Nations (1951-56). He was a Fellow of the Zoological Society of India and the Academy of Zoologists of India.

Janakiraman Ramchandran Janakiraman Ramchandran

Janakiraman Ramchandran received his Ph.D. in Biochemistry from the University of California, Berkley, in 1962. He carried out extensive studies on ACTH and other tropic hormones. He did extensive research on the structure and function of polypeptide hormones of the pituitary and the molecular basis of transmembrane signaling through cell surface receptors and ion channels. He spearheaded the development of highly selective neuronal calcium channel antagonists derived from the venoms of marine, fish-eating cone snails. Dr. Ramchandran was a member of the Scientific and Technical Advisory Committee on Tropical Diseases Research for the WHO. He was a Member of the Indian Academy of Sciences (1988).

Do You Know?

In 2015, FDA approved talimogene laherparepvec (T-VEC) for the treatment of some patients with metastatic melanoma that cannot be surgically removed.

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Cancer News
Researchers report novel findings for breast cancer patients with obesity, diabetes

23 November 2021, EurekAlert

For the first time, researchers have found that exosomes (small vesicles secreted by many cell types and released into blood or nearby tissues and fluids), are involved in breast cancer progression and treatment resistance....

Over the counter antihistamines could help against cancer

24 November 2021, The Scientist

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment...

Patient-led surveillance shows promise for melanoma care

25 November 2021, MedicalXpress

The study is part of the University Sydney's MELSELF project, which is investigating how smartphone technologies can help detect melanomas earlier than usual routine follow-up...

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