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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 31st January 2022 Vol. No. 11; Issue No. 511

1. Sreevidya TS, Dalvi S, Venkatraman P, Vemparala S. (2022) Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein. Proteins: Structure, Function, and Bioinformatics

2. Mogre S, Makani V, Pradhan S, Devre P, More S, Vaidya M, D'Mello C. (2022) Biomarker potential of vimentin in oral cancers. Life. 12(2): 150.

3. Poojari R, Mohanty B, Kadwad V, Suryawanshi D, Chaudhari P, Khade B, Srivastava R, Gupta S, Panda D.(2022) Combinatorial Cetuximab targeted polymeric nanocomplexes reduce PRC1 level and abrogate growth of metastatic hepatocellular carcinoma in vivo with efficient radionuclide uptake. Nanomedicine: Nanotechnology, Biology and Medicine.

Akash Ramchandra Deogharkar. 2021. Role of Epigenetic Modifiers in pathogenesis of Medulloblastoma. (HBNI.: LIFE09201404012). (Guide: Prof. Neelam Shirsat)

Site of the Week

FindMod predicts potential protein post-translational modifications (PTM) and find potential single amino acid substitutions in peptides.

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Interesting Reads

Ozga AJ, Chow MT, Lopes ME, Servis RL, Di Pilato M, Dehio P, Lian J, Mempel TR, Luster AD. CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection. Immunity. 55(1):82-97.e8, 2022.

Legends of Science
Kalpathy Ramaier Katchap Easwaran Kalpathy Ramaier Katchap Easwaran

K R K Easwaran obtained his Ph.D. from the Indian Institute of Science in 1967. He explained the mechanistic and kinetic aspects of transmembrane ion transport mediated by carrier ionophores, which helped design and develop anti-fungal drugs, lipids, and membrane structures. He also contributed to the spectroscopic analysis of peptides and proteins. He received the Shanti Swarup Bhatnagar Award in 1984 and was the recipient of the Ranbaxy Research Award in 1994.

Dipankar Chatterji Dipankar Chatterji

Dipankar Chatterji secured his Ph.D. from the Indian Institute of Science, Bengaluru, in 1973. His specialization was in Mycobacterium tuberculosis and Escherichia coli and the Omega factor concerning the Bacterial transcription mechanism and genome expression. He was a visiting fellow at the National Insitute of Genetics, Japan, and John Hopkins University. He is an elected fellow of the World Academy of Sciences (1997); the National Academy of Sciences, India (1989). He received the Shanti Swarup Bhatnagar Award in 1992; Padma Shri in 2016.

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Do You Know?

In 2008, researchers showed results from a large-scale analysis of the pancreatic cancer genome and reported identification of 63 genetic abnormalities along 12 key pathways that are present in the vast majority of pancreatic tumors.

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Cancer News
Ground-breaking study reveals dynamics of DNA replication ‘licensing’

26 January 2022, ScienceDaily

A new study has illuminated an important process that occurs during cell division and is a likely source of DNA damage under some circumstances, including cancer...

Genetic clues link lipoprotein A to prostate cancer risk

27 January 2022, Eurekalert

A new analysis has uncovered a potential link between higher prostate cancer risk and genetic variants associated with higher bloodstream levels of the cholesterol-transporting molecule lipoprotein A...

Secondary structures in DNA are associated with cancer

03 February 2022, MedicalXpress

A new cancer study reports that DNA manifested as knot-like folds and third rungs between DNA's two strands may drive cancer development, and an important regulatory enzyme could be associated with the formation of these unusual structures...

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