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Science Sparks @ ACTREC
Date Image 3rd January 2022 Vol. No. 11; Issue No. 507

1. Ivanisenko N, Seyrek K, Hiller-Richter L, König C, Espe J, Bose K, Lavrik I (2021). Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks. Trends in Cancer.

2. Panda G, Kalra B, Rishi A, Khanna N, Kakoti S, Sridhar E, Shet T, Sengar M, Nayak L, Bagal B, Jain H, Laskar S, Goda J (2021). Long-term clinical outcomes and sequelae of therapy in early-stage orbital mucosa-associated lymphoid tissue lymphoma. Clinical Lymphoma Myeloma and Leukemia.

3. Chaturvedi P, Badwe RA (2021). With the emergence of Omicron, SARS-CoV-2 is getting weaker and human species is getting stronger due to our inherent cellular intelligence. Cancer Research, Statistics and Treatment .4: 608-10.

4. Dhumal S, Patil V, Noronha V, Joshi A, Menon N, Nawale K, Tambe R, Prabhash K (2021). Post hoc analysis of the screening log of phase III investigator-initiated randomized clinical trial comparing palliative oral metronomic versus intravenous chemotherapy in head-and-neck cancer. Cancer Research Statistics, and Treatment. 4: 642-6.

5. Rao AR, Gattani S, Castelino R, Kumar S, Dhekale R, Krishnamurthy J, Ramaswamy A, Noronha V, Gota V, Banavali S, Badwe RA, Prabhash K (2021). Utilization of technology among older Indian patients with cancer: A cross-sectional study. Cancer Research Statistics, and Treatment. 4:656-62.

6. Badwe RA, Parmar V, Nair NS (2021). Predicting pathological complete response post neoadjuvant chemotherapy and personalizing therapy in breast cancer. Cancer Research Statistics, and Treatment . 4:726-7.

7. Mirgh SP. (2021). (F)utility of day 14 bone marrow in acute myeloid leukemia on 3 + 7 induction – Is it time to bid adieu to day 14 bone marrow?. Cancer Research Statistics, and Treatment. 4:731-3.

8. Pimple S, Mishra GA (2021). Need more evidence for establishing standard vaccination practices among patients with cancer. Cancer Research Statistics and Treatment. 4:804-5.

9. MG Sudharsan M, Chikhale R, Nanaware N, Dalvi S, Venkatraman P (2022). A druggable pocket on PSMD10Gankyrin that can accommodate an interface peptide and doxorubicin. European Journal of Pharmacology. 915: 174718.

10. Pansare K, Mohanty B, Dhotre R, Pettiwala AM, Parab S, Gupta N, Gera P, Gardi N, Dugge R, Sahu P, Alhans R, Kowtal P, Chaudhari P, Sarin R (2022). Aspirin Inhibition of Group VI Phospholipase A2 Induces Synthetic Lethality in AAM Pathway Down-Regulated Gingivobuccal Squamous Carcinoma. Cells. 11(1):123.

11. Castaño-Vinyals G, Sadetzki S, Vermeulen R, Momoli F, Kundi M, Merletti F, Maslanyj M, Calderon C, Wiart J, Lee AK, Taki M, Sim M, Armstrong B, Benke G, Schattner R, Hutter HP, Krewski D, Mohipp C, Ritvo P, Spinelli J, Lacour B, Remen T, Radon K, Weinmann T, Petridou ET, Moschovi M, Pourtsidis A, Oikonomou K, Kanavidis P, Bouka E, Dikshit R, Nagrani R, Chetrit A, Bruchim R, Maule M, Migliore E, Filippini G, Miligi L, Mattioli S, Kojimahara N, Yamaguchi N, Ha M, Choi K, Kromhout H, Goedhart G, 't Mannetje A, Eng A, Langer CE, Alguacil J, Aragonés N, Morales-Suárez-Varela M, Badia F, Albert A, Carretero G, Cardis E (2022). Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study. Environment International. 160:10769.

12. Halmare N, Gaonkar PP, Sonkusale PM, Somkuwar AP, Ingle AD, Kurkure NV (2021).Evaluation of anti-cancer activity of Tinospora cordifolia on experimentally induced spontaneous fibrosarcoma in Swiss albino mice. Indian Journal of Veterinary Pathology. 45(1): 15-23.

Book Chapters

1. Yogi K, Thorat R, Shirsat NV. (2022) In Vivo Tumorigenicity Assays Using Subcutaneous and Orthotopic Xenografts in Immunodeficient Mice. In: Dey A, Malhotra A, Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

2. Panwalkar P, Khire A, Shirsat NV. (2022) Quantification of microRNAs in Cells and Tissues Using Stem-Loop RT PCR and qPCR. In: Dey A, Malhotra A, Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

3. Panwalkar P, Khire A. Shirsat NV. (2022) Validation of microRNA Target Genes Using Luciferase Reporter assay and Western Blot Analysis. In: Dey A., Malhotra A., Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

4. Kunder R, Shirsat NV. (2022) Real-Time PCR Assays on Formalin-Fixed, Paraffin-Embedded Medulloblastomas. In: Dey A, Malhotra A, Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

5. Chatterjee A, Maitre M, Dasgupta A, Sridhar E, Gupta T. (2022) Multidisciplinary Management of Medulloblastoma: Consensus, Challenges, and Controversies. In: Dey A., Malhotra A., Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

6. Dasgupta A, Maitre M, Pungavkar S, Gupta T. (2022) Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications. In: Dey A, Malhotra A, Garg N. (eds) Medulloblastoma. Methods in Molecular Biology, vol 2423. New York; Humana. (ISBN 978-1-0716-1952-0)

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Myristoylator predicts N-terminal myristoylation of proteins by neural networks.

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Interesting Reads

Bonora, M., Giorgi, C. & Pinton, P. Molecular mechanisms and consequences of mitochondrial permeability transition. Nat Rev Mol Cell Biol. 2021.

Legends of Science
Govindasamy Shanmugam Govindasamy Shanmugam

Govindasamy Shanmugam, doctorate from Regional Research Laboratory, Hyderabad was an internationally recognized Cancer Biologist. He worked on the synthesis and assembly of adenoviruses and moloney murine leukemia virus. His group isolated two potential anticancer compounds, Cleistanthin A and Cleistanthus B, from a poisonous plant and presented that both compounds induced DNA damage, growth arrest, and apoptosis in cancer cells. Dr. Shanmugam was conferred with the ICMR Award in Biomedical Sciences and he was the recipient of INSA Senior Scientist Award. He was an elected fellow of the INSA, New Delhi, Indian Academy of Sciences, Bengaluru, and National Academy of Sciences, India (Allahabad).

Satya Narain Singh Satya Narain Singh

Satya Narain Singh, DSc from the University of London, UK, was a pioneer in helminths, worked on nematodes and trematodes, adding many new taxa, parasitic mainly in birds and mammals. He was the first to show (1958) that the dermatitis in the ears of buffaloes in Andhra Pradesh is caused by Stepahanofilaria. Since then his main interest centered round filarial worms. He described many genera of nematode parasites of birds, such as Buckley fielaria and Lerouxinema and a large number of species new to science. Dr. Singh was the recipient of Dr. Bhalerao Memorial Gold Medal in 1969 and Sir Dorab Tata Gold Medal in 1968. He was elected Fellow of the Zoological Society of India and Helminthological Society of India.

Upcoming Events
2022 ASCO Gastrointestinal Cancer Symposium

20-22 January 2022

In-Person and Online, at San Francisco, CA.

2022 Oncologic Emergency Medicine Conference

21-22 January 2022

Virtual, at Houston, TX.

Seed and Soil: In Vivo Models of Metastasis

25-26 January 2022

Virtual, by European Association for Cancer Research

Do You Know?

In 1993, Results from an NCI-supported clinical trial showed that annual screening with guaiac fecal occult blood testing (FOBT) can reduce colorectal cancer mortality by about 33%.

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Cancer News
Survival odds higher for breast cancer patients with access to integrative therapies

28 December 2021, EurekAlert

For the study, researchers analyzed claims data for 4,815 newly diagnosed breast cancer patients who were treated in 2013 and 2014. Treating oncologists were surveyed about their institutions’ efforts to educate patients and to support 12 complementary and lifestyle approaches to treatment...

Scientists retool CAR T cells to serve as 'micropharmacies' for cancer drugs

30 December 2021, MedicalXpress

Scientists retool CAR T cells to serve as Standard-issue CAR T cells are designed in the lab to recognize specific markers on cancer cells. When these CAR T cells are given back to a patient, they proliferate and go on the attack, acting as a kind of "living drug."...

Degrading a protein nexus oncogenes rely on to drive prostate cancer

30 December 2021, Fierce Biotech

For their study, the researchers developed AU-15330 as a proteolysis-targeting chimera (PROTAC) degrader of the key SWI/SNF subunits SMARCA2 (BRM) and SMARCA4 (BRG1), which are required for the complex’s functions...

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