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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 4 January 2021 Vol. No. 10; Issue No. 456

1. Sinha S, Agarwal JP, Mahajan A, Chaturvedi P, Balaji A, Juvekar S, Gupta T, Budrukkar A, Murthy V, Mummudi N, Swain M, Jadhav R, Laskar SG (2020). Implications of limited exolaryngeal disease and cricoarytenoid joint involvement in organ conservation protocols for laryngopharyngeal cancers: Results from a prospective study. Head Neck.

2. Muwonge R, Basu P, Gheit T, Anantharaman D, Verma Y, Bhatla N, Joshi S, Esmy PO, Poli URR, Shah A, Zomawia E, Shastri SS, Pimple S, Prabhu PR, Hingmire S, Chiwate A, Sauvaget C, Lucas E, Malvi SG, Siddiqi M, Sankaran S, Kannan TPRA, Varghese R, Divate U, Vashist S, Mishra G, Jadhav R, Tommasino M, Pillai MR, Sankaranarayanan R, Jayant K; Indian HPV vaccine study group. Acquisition, prevalence and clearance of type-specific human papillomavirus infections in young sexually active Indian women: A community-based multicentric cohort study. PLoS One. 15(12):e0244242.

3. Bhatia A, Victora CG, Beckfield J, Budukh A, Krieger N. "Registries are not only a tool for data collection, they are for action": Cancer registration and gaps in data for health equity in six population-based registries in India. International Journal of Cancer.

Site of the Week

miROrtho contains predictions of precursor miRNA genes covering several animal genomes combining orthology and a Support Vector Machine.

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Interesting Reads

Sancar A, Gelder RN. Clocks, cancer, and chronochemotherapy. Science, 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Shyam Swarup Agarwal

Shyam Swarup Agarwal obtained his MBBS degree from King George Medical College (1963). He obtained his MD from KGMU (1967). He did his post-doctoral studies at the laboratory of Baruch Samuel Blumberg at Fox Chase Cancer Center. Agarwal's research areas were medical genetics and molecular biology. He was the pioneer of medical genetics and clinical immunology education in India. His research focused on DNA polymerase and its role in DNA synthesis which elucidated its stability as well as the mechanism of DNA repair. His other research areas include the seroepidemiology of malaria, childhood cirrhosis and its polygenic inheritance and antenatal screening for thalassemia incidence. He was the director of Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI-MS), Lucknow. He was former director of the Advanced Center for Treatment, Research and Education in Cancer (ACTREC). He was an elected fellow of all the three major Indian science academies, namely, the Indian Academy of Sciences, National Academy of Sciences, India, and the Indian National Science Academy. He was the recipient of Shanti Swarup Bhatnagar Prize (1986), Ranbaxy Research Award (1999). He was the founder fellow of the Indian College of Physicians, Emeritus Professor of the National Academy of Medical Sciences.

Andreas Vesalius Jagannath Ganguly

Jagannath Ganguly obtained his DSc from university of Reading, UK (1963). His areas of specialization were biochemistry of Vitamin-A and lipids. He isolated a new pro-vitamin-A carotenoid, echinenone, and established its structure. He demonstrated that carotene is cleaved giving retinal and a series of apocarotenals, which are eventually converted to retinoic acid. This mechanism has been accepted to be the major source of retinoic acid in the animal body. He also demonstrated that Vitamin-A is required for proliferation and differentiation of cells. He was the first to show the presence of retinal-binding protein in blood and also demonstrated the malonate pathway for fatty acid synthesis. Ganguly was the recipient of the Shanti Swarup Bhatnagar Prize (1963), FICCI award (1978), B C Guha Memorial Lecture of INSA (1975).

Do You Know?

In 1996, Mark Davis defined tetramer technology, permitting physicians to monitor patients' immune responses to cancer vaccines as well as study endogenous T cell responses to cancer.

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Cancer News
Scientists develop high-throughput mitochondria transfer device

29 December 2020, ScienceDaily

Scientists have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells...

Protein twist and squeeze confers cancer drug resistance

29 December 2020, MedicalXpress

ABCB1 is one of these proteins, and is responsible for exporting toxic compounds out of the cell in vital organs such as the brain, testes, and placenta...

Researchers discover way to boost immunotherapy against breast cancer

31 December 2020, SciTechDaily

CAR-T immunotherapy, in which T cells are modified in the laboratory to express chimeric antigen receptors, CARs, that in turn target surface proteins on cancer cells, has been most effective in the treatment of patients with B-cell leukemia or lymphoma...

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