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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 4th October 2021 Vol. No. 10; Issue No. 495

1. Deo A, Thorat R, Dhadve A, De A, Rekhi B, Ray P (2021). IGF1R-α6 integrin-S100A4 network governs the organ-specific metastasis of chemoresistant epithelial ovarian cancer cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.

2. Gatellier L, Ong SK, Matsuda T, Ramlee N, Lau FN, Yusak S, Werdi Nintindo D HRS, Jayusman AM, Syarif AH, Pradhananga KK, Yusuf A, Huong GN, Sengar M, Pramesh CS, Mosavi Jarrahi A, Suzuki T, Hwang WY.(2021) Preparing for the Next Pandemic: An Asian National Cancer Centers Alliance (ANCCA) Initiative. Asian Pacific Journal of Cancer Prevention. 22(9):2945-2950.

3. Sarkar K, Dhatrak S, Sarkar B, Ojha U, Raghav P, Pagdhune A.(2021) Secondary prevention of silicosis and silico-tuberculosis by periodic screening of silica dust exposed workers using serum club cell protein 16 as a proxy marker. Health Science Reports. 4(3): e73.

4. Mahantshetty U, Lewis S, Engineer R, Swamidas J, Chopra S, Gurram L, Kinhikar R, Deshpande D, Kirisits C, Shrivastava S (2021). Low-Dose-Rate versus High-Dose-Rate intracavitary brachytherapy in cervical cancer - Final results of a phase III randomized trial. Brachytherapy.

5. Tembhare PR, Sriram HN, Chatterjee G, Khanka T, Gokarn A, Mirgh S, Rajendra A, Chaturvedi A, Ghogale SG, Deshpande N, Girase K, Dalvi K, Rajpal S, Patkar N, Trivedi B, Joshi A, Murthy V, Shetty N, Nair S, More A, Kamtalwar S, Chavan P, Bhat V, Bhat P, Subramanian PG, Gupta S, Khattry N (2021). Comprehensive immune cell profiling depicts an early immune response associated with severe COVID-19 disease in cancer patients. Immunology andCell Biology.

6. Narasimhan M, Khamkar V, Tilwani S, Dalal SN, Shetty D, Subramanian PG, Gupta S, Govekar R (2021). Atypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia. Journal of Cell Communication and Signaling.

7. Gupta T, Manjali JJ, Purandare N, Bagal B (2021). Bone marrow biopsy in PCNSL: Relevant or redundant? Neuro Oncology.

8. Dixit H, Selvaa Kumar C, Dasgupta D, Gadewal N (2021). Molecular docking analysis of hyperphosphorylated tau protein with compounds derived from Bacopa monnieri and Withania somnifera. Bioinformation 17(9): 798-804.

9. Shetty D, Mohanty P, Talker E, Jain H, Chaubal K, Tembhare P, Patkar N, Subramanian P, Moulik NR, Dhamne C, Narula G, Banavali S (2021). Importance of conventional cytogenetics in the identification of ins(19;X)(q13.1;p11.2q28) and t(1;11)(q10;p10), both, novel cytogenetic abnormalities in a pediatric AML case. Cancer Genetics. 256-257:17-20

Site of the Week

PeptideCutter predicts potential cleavage sites cleaved by proteases or chemicals in a given protein sequence.

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Interesting Reads

Wang X, Tokheim C, Gu SS, Wang B, Tang Q, Li Y, Traugh N, Zeng Z, Zhang Y, Li Z, Zhang B, Fu J, Xiao T, Li W, Meyer CA, Chu J, Jiang P, Cejas P, Lim K, Long H, Brown M, Liu XS. In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target. Cell, 2021.

Legends of Science
Basudeva Narayana Basudeva Narayana

Basudev Narayana secured his Ph.D. from the University of Edinburgh, UK, in 1934. He investigated factors causing variations in the blood diastase levels and showed that the pancreas was not the primary source of blood diastase. He developed an improved version of a research tool - Kymograph. Investigations on the effect of evipan sodium on the heart and the impact of drugs like ergotamine, adrenalin, and pituitrin on the coronary vessels were significant. Dr. Narayana was Vice-Chancellor of Patna University. He was the President of Indian Science Congress and was a Fellow, Royal Society of Edinburgh, and Member of the International Physiological Congress.

Bishnupada Mukerjee Bishnupada Mukerjee

Bishnupada Mukerjee obtained his DSc from the University of Michigan in 1936. He contributed significantly to India's medical and pharmacological research by promoting standardization of drugs and several other medicines. He did extensive research on the effect of anterior pituitary extracts on smooth muscles under the influence of some amines related to ephedrine, effect of sodium nitrate, and methylene blue on thiocyanate formation in cyanide poisoning. He substantially contributed to the Indian Pharmacopoeia and Indian Pharmaceutical Codex. Dr. Mukerjee was the recipient of the Griffith Memorial Prize in 1938, Barclay Medal in 1954, Squibb International Award in 1962, Padma Shri in 1962, Shree Dhanwantari Medal in 1976. He was a member of several international pharmacological Societies and Associations.

Do You Know?

In 1998, the United States Food and Drug Administration (FDA) approved the first antisense oligonucleotide drug, fomivirsen, for the treatment of cytomegalovirus (CMV) retinitis in individuals with AIDS.

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Cancer News
Rare cancer of immune cells linked to gene mutations in bone marrow and smoking

28 September 2021, MedicalXpress

The researchers used next-generation genome sequencing to analyze 537 genes in 27 patients with AITL or PTCL for genetic changes that might lead to these T-cell tumors and to secondary cancers in some patients...

AI improves precision in breast cancer diagnosis

29 September 2021, EurekAlert

Researchers at Karolinska Institutet in Sweden have developed an AI-based tool that improves the diagnosis of breast cancer tumours and the ability to predict the risk of recurrence. The greater diagnostic precision can lead to more personalised treatment for the large group of breast cancer patients with intermediate risk tumours...

Looking beyond DNA to see cancer with new clarity

30 September 2021, ScienceDaily

Researchers have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease. The work points the way to identifying new precision treatments that may avoid the side effects common with much current chemotherapy...

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