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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 8 March 2021 Vol. No. 10; Issue No. 465

1. Ganesan P, Jain H, Bagal B, Subramanian PG, George B, Korula A, Mehra N, Kalaiyarasi JP, Bhurani D, Agrawal N, Ahmed R, Kayal S, Bhattacharyya J, Yanamandra U, Kumar S, Philip CC, John MJ, Nadaraj A, Karunamurthy O, Lakshmanan J, Mathews V, Sengar M (2021). Outcomes in adolescent and young adult acute lymphoblastic leukaemia: A report from the Indian Acute Leukaemia Research Database (INwARD) of the Hematology Cancer Consortium (HCC). British Journal of Haematology.

2. Sood S, Gurram L, Aravindakshan D, Paul J, Chopra S, Swamidas J, Patil A, Mahantshetty U (2021). Reporting of dose-volume specifications for "Martinez Universal Perineal Interstitial Template-based interstitial high-dose-rate brachytherapy for gynecological cancers" according to International Commission on Radiation Units and Measurements 58 with early clinical outcomes. Brachytherapy.

3. Kummari R, Dutta S, Patil S, Pandav-Mudrale S, Bose K (2021). Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2. Biochemical Journal.

4. Bajpai J, Simha V, Shylasree TS, Sarin R, Pathak R, Popat P, Mokal S, Dandekar S, Ghosh J, Nair N, Gulia S, Rath S, Joshi S, Wadasadawala T, Sheth T, Parmar V, Banavali SD, Badwe RA, Gupta S (2021). Pregnancy associated breast cancer (PABC): Report from a gestational cancer registry from a tertiary cancer care centre, India. Breast. 56: 88-95.

5. Jain H, Shetty D, Roy Moulik N, Narula G, Subramanian PG, Banavali S (2021). A novel case of intrachromosomal amplification and insertion of RUNX1 on derivative chromosome 2 in pediatric AML. Cancer Genetics.

6. Bhattacharjee A, Hole A, Malik A, Sahu A, Singh SP, Deshmukh A, Nair S, Chaturvedi P, Murali Krishna C (2021). Risk prediction by Raman spectroscopy for disease-free survival in oral cancers. Lasers Medical Science.

7. Sunkara RR, Koulgi S, Jani V, Gadewal N, Sonavane U, Joshi R, Waghmare SK (2021).Understanding the binding affinities between SFRP1CRD, SFRP1Netrin, Wnt5B and frizzled receptors 2, 3 and 7 using MD simulations. Journal of Biomolecular Structure and Dynamics.

8. Kumar A, Wadasadawala T, Laskar SG, Gondhowiardjo S, Agarwal JP (2021). Mental health impact of COVID-19 in radiation oncology health care workers of Asian Countries. Clinical Oncology (R Coll Radiol).

Ramchandra V Amnekar( 2021). Phosphoacetylation of histones during cellular transformation in mammalian cells. ( HBNI: LIFE09201304005) ( Guide: Sanjay Gupta)

Site of the Week

RNAcentral is a public resource that offers integrated access to a comprehensive and up-to-date set of non-coding RNA sequences provided by a collaborating group of Expert Databases

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Interesting Reads

Krook MA, Reeser JW, Ernst G, Barker H, Wilberding M, Li G, Chen HZ, Roychowdhury S. Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance. Br J Cancer. 124(5): 880-892, 2021.

Legends of Science
Rudolf Ludwig Carl Virchow Shamala Pai

Shamala Pai obtained her PhD (1961) from University of Bombay under the guidance of Dr. V. R. Khanolkar, a pathologist of repute and the founder of the Indian Cancer Research Centre (ICRC). She worked as a visiting Associate in the Carcinogen Screening section of NCI’s Carcinogenesis Studies Branch (1962-1964) in collaboration with scientists from NIH. She conducted studies on hormonal factors in rats treated with a chemical carcinogen causing liver tumors. These studies demonstrated the direct effect of pituitary hormones in liver carcinogenesis. This success opened up an entire field of investigation. She made significant contribution to understand the complex factors involved in liver cancer. An application of these studies is the testing of other carcinogens which are time-consuming to detect with presently available techniques because of their low potency. She was the Ex. Vice-President, Bombay City Council for Child welfare.

Andreas Vesalius Veronica Rodrigues

Veronica Rodrigues obtained her PhD (1981) from TIFR, Mumbai. She went on to obtain a post-doctoral training from Max-Planck Institut Fur Biologische Kybernetik, Tuebingen, Germany. She pioneered the study of coding of olfactory information in the brain. She showed that information about odors is encoded as pattern of activation across neurons within the olfactory lobe of Drosophila. She returned to join TIFR again in 1985. In her laboratory, she worked to understand how chemosensory circuits develop to allow complex function and what are the ways using which circuits can be modified to adapt to a varying environment. She received the Senior National Woman Bio scientist Award (2004), the Golden Jubilee Commemoration Medal (Biological Sciences) (2004) by INSA, the National Woman Bioscience Award (2004) and the JC Bose Fellowship (2007).

Do You Know?

In 1926, The British immunologist Alexander Thomas Glenny recognized the immunostimulatory properties of aluminium salts and used alum to boost the effectiveness of the diphtheria toxoid vaccine. olated

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Cancer News
Lower Radiotherapy Dose Shows Promise for Treating HPV-Related Oropharyngeal Cancer

03 March 2021, CancerNetwork

In this study, investigators used pre- and intratreatment dynamic fluorine-18–labeled fluoromisonidazole PET to evaluate tumor hypoxia in 19 patients. Patients without hypoxia at baseline or intratreatment received 30 Gy of chemoradiotherapy, and those with persistent hypoxia received 70 Gy...

Engineered safety switch curbs severe side effects of CAR-T immunotherapy

04 March 2021, EurekAlert

With CAR-T therapy, T-cells from a patient's immune system are modified in a manufacturing facility to express part of an antibody that can bind to a surface protein on cancer cells. The modified T-cells, after being infused back into the patient, seek out and attack cancer cells throughout the body…

Proteomics analysis identifies potential drug targets for aggressive human cancers

04 March 2021, ScienceDaily

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets...

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