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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 17 April 2023 Vol. No. 12; Issue No. 574

1. Verma T, Natu A, Khade B, Gera P, Gupta S (2023). An increase in polyadenylation of histone isoforms, Hist1h2ah and Hist2h3c2, is governed by 3'-UTR in de-differentiated and undifferentiated hepatocyte. Experimental Biology & Medicine.

2. Gawali P, Saraswat A, Bhide S, Gupta S, Patel K (2023). Human solid tumors and clinical relevance of the enhanced permeation and retention effect: a 'golden gate' for nanomedicine in preclinical studies? Nanomedicine.

3. Burikhanov R, Ganguly S, Ellingson S, Sviripa VM, Araujo N, Li S, Venkatraman P, Rao M, Choughule A, Brainson CF, Zhan CG, Spielmann HP, Watt DS, Govindan R, Rangnekar VM (2023). Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition. American Journal of Cancer Research. 13(3):976-991.

4. Nautiyal A, Jha AK, Konuparamban A, Mithun S, Srichandan T, Puranik A, Gala K, Shetty N, Kulkarni S, Rangarajan V (2023). A dosimetric comparison of systemic peptide receptor radionuclide therapy and intra-arterial peptide receptor radionuclide therapy in patients with liver dominant gastroenteropancreatic neuroendocrine tumours. Nuclear Medicine Communications.

5. Das S, Sakhare N, Kumar D, Mathur A, Mirapurkar S, Sheela M, Mohanty B, Chaudhari P, Chakraborty S (2023). Design, characterization and evaluation of a new 99mTc-labeled folate derivative with affinity towards folate receptor. Bioorganic & Medicinal Chemistry Letters. 86: 129240.

6. Ramaswamy A, Shah D, Bhargava P, Srinivas S, Kannan S, Shah M, Suman M, Das S, Trikha M, Ostwal V (2023). Modified FOLFIRINOX compared to Gemcitabine & nab-Paclitaxel in advanced pancreatic ductal adenocarcinoma - results of a match-pair analysis. Indian Journal of Medical Research. 157(1):57-65.

7. Jha AK, Mthun S, Sherkhane U, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L (2023). Systematic review and meta-analysis of prediction models used in cervical cancer. Artificial Intelligence in Medicine.

8. Syamprasad NP, Rajdev B, Jain S, Panda S, Rao Puppala E, Chaudhari P, Rao Vaidya J, Kumar GJ, Naidu VGM (2023). Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis. International Immunopharmacology.119: 110145.

9. Chilukuri S, Mallick I, Agrawal A, Maitre P, Arunsingh M, James FV, Kataria T, Narang K, Gurram BC, Anand AK, Utreja N, Dutta D, Pavamani S, Mitra S, Mallik S, Mahale N, Chandra M, Chinnachamy AN, Shahid T, Raghunathan MS, Kannan V, Mohanty SK, Basu T, Hotwani C, Panigrahi G, Murthy V (2023). Multi-institutional clinical outcomes of biopsy gleason grade group 5 prostate cancers treated with contemporary high-dose radiation and long-term androgen deprivation therapy. Clinical oncology.

Site of the Week

EMDB (the Electron Microscopy Data Bank) is a public repository for electron cryo-microscopy maps and tomograms of macromolecular complexes and subcellular structures.

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Interesting Reads

Campbell KM, Amouzgar M, Pfeiffer SM, Howes TR, Medina E, Travers M, Steiner G, Weber JS, Wolchok JD, Larkin J, Hodi FS, Boffo S, Salvador L, Tenney D, Tang T, Thompson MA, Spencer CN, Wells DK, Ribas A (2023). Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma. Cancer Cell. 41(4):791-806.e4.

Legends of Science
Sivaraj Ramaseshan Sivaraj Ramaseshan

Sivaraj Ramaseshan obtained his DSc from Nagpur University in 1951. His primary research areas included X-ray crystallography, anomalous scattering of X-rays and neutrons, and high-pressure physics. He contributed significantly to materials science, fibre-reinforced composites, electro-composites and new fabrication methods. He was elected Vice President of the International Union of Crystallography. He was the recipient of the S S Bhatnagar Award (1966); VASVIK Award (1980); Aryabhatta Medal by INSA (1985), and Padma Bhushan Award (1985). He was the elected Fellow of the Indian Academy of Sciences, Bangalore.

Satish Chandra Maheshwari Satish Chandra Maheshwari

Satish Chandra Maheshwari received his PhD from the University of Delhi in 1958. He is known for his pioneering research in Plant Molecular Biology. He did extensive research on embryology, morphology and flowering in duckweeds. His significant contribution was the discovery of RNA polymerase activity in chloroplasts. He also developed a new high-speed culture technique for producing pure homozygous lines of haploid plants. He was the recipient of the S S Bhatnagar Award in 1972; J C Bose Gold Medal; Birbal Sahni Gold Medal. He was the elected Fellow of the Indian Academy of Sciences; Indian National Science Academy, and the National Academy of Sciences.

Upcoming Events
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20-23 June, 2023

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24-25 July, 2023

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Do You Know?

In 1937, Sir Geoffrey Keynes recommended radiation therapy in addition to surgery to spare the breast.

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Cancer News
Identifying Cancer Genes’ Multiple Personalities

10 April 2023, Neurosciene News

A new method using the gene-editing tool CRISPR-Cas9 has been developed to model liver cancer tumor subtypes caused by mutations in the same genes. By targeting a single section of the mouse gene, Ctnnb1, researchers were able to produce two distinct tumor subtypes, enhancing protein activity to promote tumor growth, which could allow for the development of new therapeutic interventions in the future...

Complete treatment critical for survival of prostate cancer patients: Study

11 April 2023, The Federal

A study based on Population Based Cancer Registries (PBCRs) has revealed that there is an essential link between the completion of prostate cancer treatment and patient survival. Researchers from the Tata Memorial Centre (TMC), Mumbai, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab government and Chandigarh administration conducted a study in Sangrur and Mansa districts of Punjab...

Extrachromosomal DNA appears before cancer forms

12 April 2023, Nature

A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation...

2023 Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)