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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 18th July 2022 Vol. No. 11; Issue No. 535

1. Dey P, Joshi M, Mujawar A, Malhotra R, De A (2022). Direct knockdown of phospho-PTM targets mediated by TRIM21 can improve personalized treatment in breast cancer. Cellular Oncology (Dordr).

2. Sitani K, Parghane R, Talole S, Basu S (2022). The efficacy, toxicity and survival of salvage retreatment PRRT with 177Lu-DOTATATE in patients with progressive NET following initial course of PRRT. British Journal of Radiology.

Book Chapter
Mujawar A, De A. (2022). In vivo assessment of protein-protein interactions using BRET assay. In: Kim SB. (Ed.) Bioluminescence. Methods in Molecular Biology, vol 2525. New York; Humana.

Site of the Week

Cancer Single-cell Expression Map is a a public database dedicating to collecting, analyzing, visualizing single-cell RNA-Seq data of human cancers.

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Interesting Reads

Arter C, Trask L, Ward S, Yeoh S, Bayliss R. Structural features of the protein kinase domain and targeted binding by small molecule inhibitors. J Biol Chem. 102247, 2022.

Legends of Science
Mahitosh Mandal Mahitosh Mandal

Mahitosh Mandal secured his Ph.D. from the Indian Institute of Chemical Biology. His main research areas include cancer therapeutics, drug delivery, therapeutic resistance, and diagnostics. Their team is evaluating several possible biomarkers and their efficacy in targeted therapy. The molecular mechanisms promoting radio and chemoresistance in cancer are being deciphered. He is an elected fellow of the National Academy of Sciences, Allahabad, and the Indian Academy of Sciences, Bengaluru. Dr. Mandal also received Basanti Devi Amir Chand Award by ICMR; Prof. S. S. Katiyar Endowment Award by the Indian Science Congress; Subha Mukherjee Memorial Award by the Physiological Society of India.

Ashok Sadanand Kolaskar Ashok Sadanand Kolaskar

Ashok Kolaskar obtained his Ph.D. from the Indian Institute of Science, Bengaluru, in 1976. His areas of research are bioinformatics, molecular immunology, and computational chemistry. He initiated the nucleic acid sequence data analysis in India and developed a simple but accurate method to predict protein-coding regions in prokaryotic DNA. A numerical coding system developed by him that codes complete properties is used to prepare the world's largest computerized data bank for animal viruses. He is an elected fellow of the Indian Academy of Sciences, Bengaluru, and Maharashtra Academy of Sciences. He received the PARAM award from the Centre for Development of Advanced Computing.

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Do You Know?

In 2017, The FDA approved the use of enasidenib for adult patients with relapsed or refractory acute myeloid leukemia.

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Cancer News
Immunotherapy’s Skin Side Effects: Are Microbes to Blame?

13 July 2022, National Cancer Institute

A new study in mice suggests that the skin side effects may occur because the drugs cause the immune system to attack new microbes that take up residence on the skin...

Scientists discover genes that affect risk of developing pre-leukemia

14 July 2022, MedicalXpress

The team found that clonal haematopoiesis accelerated the process of biological aging itself and influenced the risk of developing atrial fibrillation, a condition marked by irregular heartbeats...

Preoperative combination chemotherapy improved survival in patients with pancreatic cancer

14 July 2022, EurekAlert

The objective of this study was to evaluate two neoadjuvant regimens for borderline resectable pancreatic cancer – one that uses FOLFIRINOX chemotherapy alone (fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) and one that uses systemic chemotherapy followed by stereotactic body radiation therapy (SBRT)...

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