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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 21 November 2022 Vol. No. 11; Issue No. 553

1. Ostwal V, Ramaswamy A, Bhargava P, Srinivas S, Mandavkar S, Chaugule D, Peelay Z, Baheti A, Tandel H, Jadhav V, Shinde S, Jadhav S, Gota V, Mittra I (2023). A pro‑oxidant combination of resveratrol and copper reduces chemotherapy‑related non‑haematological toxicities in advanced gastric cancer: results of a prospective open label phase II single‑arm study (RESCU III study). Medical Oncology. 40:17.

2. Mukund Sudharsan MG, Dalvi S, Venkatraman P (2022). Snapshots of urea-induced early structural changes and unfolding of an ankyrin repeat protein at atomic resolution. Protein Science.

3. D'Silva SZ, Tambe M, Pinto AS, Singh M (2022). Identification of the novel HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 alleles in individuals from India. HLA.

4. Barrios C, de Lima Lopes G, Yusof MM, Rubagumya F, Rutkowski P, Sengar M (2022). Barriers in access to oncology drugs - A global crisis. Nature Reviews Clinical Oncology

5. Krishnamurthy R, Mummudi N, Goda JS, Chopra S, Heijmen B, Swamidas J (2022). Using artificial intelligence for optimization of the processes and resource utilization in radiotherapy. JCO Global Oncology

6. Bhatia N, Vatsa R, Dhingra VK, Dhawan DK, Chadha VD (2022). Evaluation of tetrofosmin cold kit fractionation using alternative new method of quality control for testing radiochemical purity. World Journal of Nuclear Medicine. 21(4): 314-319.

Site of the Week

R-BIND dataset includes only bioactive ligands with demonstrated activity in cell culture and/or animal models and is subdivided into two libraries, small molecules (SM) and large molecules (LM).

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Interesting Reads

Sridaran D, Chouhan S, Mahajan K, Renganathan A, Weimholt C, Bhagwat S, Reimers M, Kim EH, Thakur MK, Saeed MA, Pachynski RK, Seeliger MA, Todd Miller W, Feng FY, Mahajan NP. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nat Commun. 13(1): 6929, 2022.

Legends of Science
Krishna Sahani Bilgrami Krishna Sahani Bilgrami

Krishna Sahani Bilgrami received his DSc from the University of Allahabad in 1962. His research interest was in fungal physiology, mycotoxicology, and ecology. He demonstrated the significance of transglycosylation in bread and fungi's utilization of complex carbohydrates. He studied the impact of industrial and urban effluents on the biodiversity of river Ganga and thermal springs in Bihar, as well as the effect of various mycotoxins on critical physiological and biochemical processes of animals and plants. He was a member of the Ganga Project Directorate Research Committee, Agricultural Research Committee, Wetland Management Committee, and ICMR Taskforce Committee. He was a Member of the INSA Council (1992-93). 'Professor Krishna Bilgrami Memorial Medal' was instituted in his honor by the INSA.

Himadri Kumar Mookerjee Himadri Kumar Mookerjee

Himadri Kumar Mookerjee obtained his DSc from the University of London in 1930. His specialization was embryology of vertebral columns and later fisheries. He postulated the hypothesis of a common structural basis for the development and evolution of the vertebral centra in the chordates. He did significant work on the development of the vertebral column from the embryonic state and the evolution of the column. He set forth that the modes of formation of the centra follow the same pattern in all the chordates. He was a member Asiatic Society, Vice-President (1955); He served as the President Indian Science Congress (1936).

Upcoming Events
Toxic Metabolites in the Biology of Ageing and Cancer

04-07 December, 2022

At Buxted Park, East Sussex, UK.

The Protein Phosphatases Conference

11-15 December, 2022

At Palm Springs, CA.

42nd Annual Conference of the Indian Association for Cancer Research

12-16 January, 2022

At Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai.

Do You Know?

In 1994, FDA approved BCG, a bacterial vaccine, for the treatment of bladder cancer, based on results of a clinical trial conducted by Memorial Sloan Kettering urologic surgeon Harry Herr and tumor immunologist Herbert Oettgen.

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Cancer News
Lab-grown bone marrow may unlock personalized blood cancer treatments

16 November 2022, NEW ATLAS

By using stem cells as a starting point, scientists have managed to produce lab-grown versions of an impressive array of human body parts. The list so far includes brains, blood vessels and lungs, and is growing rapidly, with these miniaturized models serving as next-gen research tools to study disease and develop drugs that can improve outcomes for patients...

Selective nodal radiation may be a more effective approach in cancer treatment

16 November 2022, MedicalXpress

A promising new study released by the University of Colorado Cancer Center suggests that recurrence of certain cancers can be significantly decreased by irradiating only a select set of lymph nodes near a tumor rather than all of them...

Machine learning can help predict patient response to cancer immunotherapy

16 November 2022, EurekAlert

In a small study, researchers successfully trained a machine learning algorithm to predict, in hindsight, which patients with melanoma would respond to treatment and which would not respond...

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