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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 24th October 2022 Vol. No. 11; Issue No. 549

1. Sandbhor P, Goda J, Mohanty B, Gera P, Yadav S, Chekuri G, Chaudhari P, Dutt S, Banerjee R (2022). Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model. Drug Delivery and Translational Research.

2. Banerjee A, Halder A, Jadhav P, Sarkar A, Hole A, Shastri J, Agrawal S, CM Krishna, Srivastava S (2022). SARS-CoV-2 severity classification from plasma sample using Confocal Raman spectroscopy. Journal of Raman Spectroscopy.

3. Chopra S, Ranjan N, Charnalia M, Kannan S, Engineer R, Dora T, Gurram L, Mittal P, Maheshwari A, Shylasree TS, Shrivastava S, Gupta S (2022). Late toxicity within a Phase III clinical trial of IG-IMRT in cervix cancer (PARCER): Reanalysis with time weighted adverse event reporting (MOSES). Radiotherapy and Oncology.

4. Patil VM, Noronha V, Menon N, Rai R, Bhattacharjee A, Singh A, Nawale K, Jogdhankar S, Tambe R, Dhumal S, Sawant R, Alone M, Karla D, Peelay Z, Pathak S, Balaji A, Kumar S, Purandare N, Agarwal A, Puranik A, Mahajan A, Janu A, Kumar Singh G, Mittal N, Yadav S, Banavali S, Prabhash K (2022). Low-Dose Immunotherapy in Head and Neck Cancer: A Randomized Study. Journal of Clinical Oncology.

5. Johnson S, Dhamne C, Sankaran H, Gandhi KA, Rane P, Moulik NR, Jadhav SM, Gurjar M, Narula G, Banavali S, Gota V (2022). A prospective, open-label, randomised, parallel design study of 4 generic formulations of intramuscular L-asparaginase in childhood precursor B-cell acute lymphoblastic leukaemia (ALL). Cancer Chemotherapy and Pharmacology.

6. Guha A, Goda JS, Dasgupta A, Mahajan A, Halder S, Gawde J, Talole S (2022). Classifying primary central nervous system lymphoma from glioblastoma using deep learning and radiomics based machine learning approach - a systematic review and meta-analysis. Frontiers in Oncology.

Site of the Week

The DICE (Database of Immune Cell Expression, Expression quantitative trait loci (eQTLs) and Epigenomics) datasets helps to reveal the effects of disease risk-associated genetic polymorphisms on specific immune cell types, providing mechanistic insights into how they might influence pathogenesis.

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Interesting Reads

Brown LC, Zhu J, Desai K, Kinsey E, Kao C, Lee YH, Pabla S, Labriola MK, Tran J, Dragnev KH, Tafe LJ, Dayyani F, Gupta RT, McCall S, George DJ, Glenn ST, Nesline MK, George S, Zibelman M, Morrison C, Ornstein MC, Zhang T (2022). Evaluation of tumor microenvironment and biomarkers of immune checkpoint inhibitor response in metastatic renal cell carcinoma. J Immunother Cancer. 10(10): e005249.

Legends of Science
Nedumangattu Kesava Panikkar Nedumangattu Kesava Panikkar

Nedumangattu Kesava Panikkar received his DSc from the University of Madras in 1938. His Specialization was in Crustacean physiology, marine fisheries, and oceanography. Under his leadership, India made significant contributions to studying the Indian Ocean. He was instrumental in establishing the Central Marine Fisheries Research Institute, Central Inland Fisheries Research Institute, and Central Institute of Fisheries Technology. Dr. Panikkar was the recipient of The Galatheca Medal of Denmark in 1953; the Padma Shri in 1973; Sir Dorabaji Tata Medal in 1961. He was elected Fellow of the Indian Academy of Sciences, Bangalore; National Academy of Sciences, Allahabad.

Navalpakkam Parthasarathy Navalpakkam Parthasarathy

Navalpakkam Parthasarathy obtained his Ph.D. from the University of London, the UK, in 1938. He made significant contributions to the cytology and genetics of sugarcane and rice. His primary research achievement was related to the induction of mutations in X-irradiation. Dr. Parthasarathy was conferred with the Padma Shri Award in 1958. He was elected Fellow of the Tamil Nadu Academy of Sciences; Indian Society of Genetics and Plant breeding; Indian Science Congress.

Upcoming Events
The fundamentals of high-end cell sorting

30 October-04 November, 2022

At EMBL Heidelberg.

Volume electron microscopy by automated serial SEM

06-11 November, 2022

At Lausanne, Switzerland.

Scholars World Congress on Cancer Research and Oncology

14-15 November, 2022

At TIME Asma Hotel, Albarsha Dubai, UAE & Online (Hybrid event).

Do You Know?

In 1953, Roy Hertz and Min Chiu Li achieved the first complete cure of a human solid tumor by chemotherapy when they used the drug methotrexate to treat a patient with choriocarcinoma, a rare cancer of the reproductive tissue that mainly affects women.

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Cancer News
Skin and brain cancers: New discovery may help improve treatment

17 October 2022, MedicalNewsToday

study helps to explain at a molecular level how errors in Hedgehog signaling can lead to birth defects or cancer. Having this knowledge help scientists and clinicians understand these diseases at a more fundamental level...

Researchers identify a gene as a potential target in treatment-resistant brain cancer glioblastoma multiforme

19 October 2022, MedicalXpress

By performing single-cell transcriptomic sequencing, which can identify molecular changes in cancerous cells, the UCLA-led research team showed that radiation therapy-induced stress promotes phenotypic conversion of glioma stem cells to resemble two types of cells that are normally found in blood vessels (vascular endothelial-like cells and pericyte-like cells)...

Gel-like, radioactive tumor implant obliterates pancreatic cancer in mice

20 October 2022, EurekAlert

This new treatment completely eliminated tumors in 80% of mice across several model types, including those considered the most difficult to treat...

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