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Science Sparks @ ACTREC
Date Image 6 March 2023 Vol. No. 12; Issue No. 568

1. Dhumal S, Patil V, Parekh D, Noronha V, Menon N, Peelay Z, Nawale K, Prabhash K (2023). Long term outcomes of phase I/II study of palliative triple metronomic chemotherapy in platinum-refractory/early failure oral cancer. Lancet Regional Health – Southeast Asia

2. Mailankody S, Bajpai J, Budukh A, Swaminathan R, Dikshit R, Dhimal M, Perera S, Tshomo U, Bagal S, Bhise M, Chaturvedi P, Banavali S, Gupta S, Badwe R, Trama A. (2023) Epidemiology of rare cancers in India and South Asian countries-remembering the forgotten. Lancet Regional Health - Southeast Asia.

3. Ambulkar R, Parab S, Vignesh B, Nagargoje V, Janu A, Parikh P, Moiyadi A.(2023) A prospective study to evaluate the use of surveillance venous ultrasonography to detect incidence of deep venous thrombosis following neurosurgical excision of brain tumors. Journal of Neurosciences in Rural Practice.

4. Paul S, Gupta T, Purandare N, Joshi K, Ghosh-Laskar S, Budrukkar A, Swain M, Sinha S, Kumar A, Joshi A, Prabhash K, Nair S, Rangarajan V, Agarwal JP (2023). Diagnostic performance of response assessment FDG-PET/CECT in HNSCC treated with definitive Radio(chemo)therapy using NI-RADS. Otolaryngology- Head and Neck Surgery.

5. Patil S, Ambulkar R, Kulkarni A. (2023) Patient safety in intensive care unit: What can we do better? Indian Journal of Critical Care Medicine. 27(3): 163-165.

6. Majithia J, Mahajan A, Vaish R, Prakash G, Patwardhan S, Sarin R (2023). Imaging recommendations for diagnosis, staging, and management of hereditary malignancies. Indian Journal of Medical and Paediatric Oncology.

7. Krishnatry R, Mani S, Manjali JJ, Rane PP, Chatterjee A, Goda JS, Janu A, Sahu A, Gupta T, Jalali R (2023). Institutional patterns of care of diffuse intrinsic pontine glioma. Neurology India. 71(1):72-78.

Site of the Week

The database of Genotypes and Phenotypes (dbGaP) archives and distributes the data and results from studies that have investigated the interaction of genotype and phenotype in Humans.

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Interesting Reads

Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature. 615(7950): 168-174, 2023.

Legends of Science
Veena Parnaik Veena Parnaik

Veena Parnaik obtained her PhD from the Ohio State University, Columbus, USA, in 1979. Her main research area was to understand the functional role of the nuclear lamina, especially fibrous proteins found in the nuclear lamina that provide structural support and are essential for proper cell differentiation and gene regulation. Through her research, she made considerable progress in understanding the role of nuclear lamins during embryonic development. She was the President of the Indian Society of Cell Biology (2011-13); was a member of the Centre for DNA fingerprinting and Diagnostics, Hyderabad ( 2006-15). She received the Shakuntala Devi Amirchand Prize of ICMR in 1992. She was the recipient of the J C Bose National Fellowship. She was an elected fellow of the Indian Academy of Sciences, Bangalore.

Kamala Sohonie Kamala Sohonie

Kamala Sohonie, the first Indian Woman to gain a PhD in science, obtained her PhD from the Cambridge University, Uk in 1939. Her research topics were proteins in milk, pulses and legumes. She discovered the enzyme Cytochrome C which plays an important role in the electron transport chain found in plants, human and animal cells. She did pioneering work on Neera (sap extract from the inflorescence of various species of toddy palms) by finding important qualities of Vitamin A, Vitamin C and iron. She was awarded Rashtrapati Award for her work. She was Elected President (1982-83) of the Consumer Guidance Society of India.

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26-29 March, 2023

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Chromatin Modifications in Health and Disease

11-16 June, 2023

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Do You Know?

In 2007, FDA approved Nexavar (sorafenib) for primary liver cancer, making it the only drug approved for liver cancer.

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Cancer News
Bleb protrusions help cancer cells to cheat death

01 March 2023, Nature

Processes that regulate cell death can rid the body of cancer cells. However, some of these cells have ways to thwart such processes, and one such death-defying mechanism has been found to rely on cellular protrusions called blebs...

AI predicts cancer patient survival by reading doctor's notes

02 March 2023, MedicalXpress

The model uses natural language processing (NLP), a branch of AI that understands complex human language to analyze oncologist notes following a patient's initial consultation visit...

Machine learning to identify cancer type-specific driver mutations for the development of new drug targets and treatment strategies

02 March 2023, EurekAlert

This technology can identify novel oncogenic driver mutations that were previously undetectable to help design distinct strategies for cancer diagnosis and treatment that are different from conventional methods...

2023 Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)