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Advanced Centre for Treatment Research & Education in Cancer
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Science Sparks @ ACTREC
Date Image 11th December 2023 Vol. No. 12 ; Issue No. 608

1. Colaco V, Goswami N, Goel VK, Srivastava SK, Lalrohlua P, Senthil Kumar N, Borah P, Baruah R, Varma AK (2023). In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase. Journal of Cellular Biochemistry.

2. Ghantasala S, Bhat A, Epari S, Moiyadi A, Srivastava S. High-grade gliomas from subventricular zone: Proteomic drivers of aggressiveness using fluorescence-guided multiple sampling. OMICS: A Journal of Integrative Biology (2023).

3. Vahabi M, Shahil-Feroz A, Lofters A, Wong JP, Prakash V, Pimple S, Anand K, Mishra G (2023). Surviving the Storm: The Impact of COVID-19 on Cervical Cancer Screening in Low- and Middle-Income Countries. Healthcare. 11(23): 3079.

4. Huck C, Achard V, Maitre P, Murthy V, Zilli T. Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction: Impact on urinary morbidity and mitigation strategies. Clinical and Translational Radiation Oncology.

Site of the Week

IntAct provides a free, open source database system and analysis tools for molecular interaction data.

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Interesting Reads

Taifour T, Attalla SS, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee CG, Kamle S, Siegel PM, Elias JA, Park M, Muller WJ (2023). The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer. Immunity.

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Gut and Intratumoral Microbiome: Diagnostic and Therapeutic Implications
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Do You Know?

In 2001, Results of a clinical trial showed that the drug imatinib mesylate, which targets a unique protein produced by the Philadelphia chromosome, is effective against chronic myelogenous leukemia (CML).

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Cancer News
Novel and promising pancreatic cancer organoids for effective screening of anticancer drugs.

ScienceDaily, 07/12/2023

Researchers have now created a pancreatic ductal adenocarcinoma (PDAC) organoid model using human-induced pluripotent stem cell (hiPSC) technology, simulating desirable TME properties. Their research findings have far-reaching consequences in the field of cancer biology…

Exploring novel leukemia therapies using the 'the complex alphabet of mRNA.

MedicalXpress, 07/12/2023

The researchers demonstrated that the SRSF2 protein reads the m5C modification in RNA; they also highlighted a previously unsuspected molecular mechanism that can lead to leukemia: the mutation of SRSF2 alters its ability to read m5C in RNA, which inhibits its function of regulating messenger RNA…

Cancer therapy bexmarilimab awakens immune cells to attack tumors that have avoided the detection of the immune system.

EurekAlert, 07/12/2023

In a clinical trial for advanced-stage cancer, bexmarilimab therapy was well tolerated and stabilized disease progression in subsets of patients. In patients benefitting from the therapy, we observed tumor-associated macrophage and lymphocyte activation as well as induction of interferons, which are all important signs of anti-tumoral immune defense...

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