Head and neck cancer is the sixth common malignancy and a major cause of cancer morbidity and mortality worldwide and oral cavity is one of the most commonly affected sites. Worldwide over 350,000 to 400,000 new cases of cancer are reported each year. Cancers of Head and Neck comprises ~24.1 % of total cancers seen at the Tata Memorial Centre, Mumbai, of these ~13.5 % are from the Oral cavity. In the post genomic era, efforts to understand oral cancer are aimed at obtaining genomic and proteomic profiles which generate enormous data. Thus the challenge is to analyze the data effectively and utilize the information for diagnosis, prognosis and treatment.

OrCGDB (http://www.tumor-gene.org/Oral/oral.html) oral cancer gene database has information for only 15 genes without a search engine and interaction network. Our first database with 242 genes was made in 2007 and is available at (http://www.actrec.gov.in/oralcancer/GeneHome.htm). The present database, version II, has been updated to include 374 genes. It has been developed as a user friendly site that would provide the scientist, information and external links from one place.