Despite the spectacular advances made in cancer imaging/monitoring modalities and treatment protocols, cancer treatment often yields limited success stemming from notorious factors namely metastasis, chemo/radioresistance and bystander (non-targeted) effects of therapeutic agents. Hence, investigating multiple facets of cancer biology in an integrative manner to discover the Achilles heel of cancer is of paramount importance for development of smart and effective theranostics. The broad goal of Patwardhan laboratory is to understand multifactorial regulation of cancer exacerbation. With a holistic approach of unravelling signaling networks induced by biochemical and biophysical cues encoded by tumor microenvironment, we aim to identify key regulators at the crossroads of cancer metastasis, therapy resistance and bystander effects in lung and breast cancer models. To achieve this, we employ various approaches covering proteomics, genomics, cell biology and cellular biophysics. Intriguingly, the key regulators projected from basic research are also evaluated in clinical scenarios to test their translational potential either as diagnostic/prognostic biomarkers or as therapeutic targets with the ultimate aim of improving the therapeutic gain.
Extracellular matrix (ECM) is a meshwork of proteins that assimilates cells into tissue. Mechanical rigidity (st… more
LK Sthanam, T Roy, Sejal Patwardhan, A Shukla, S Sharma, PV Shinde, HT Kale, PC Shekhar, K Kondabagil, S Sen
Sejal Patwardhan*, P Mahadik, O Shetty, S Sen* (* Corresponding author)
MMS Balla#, Sejal Patwardhan#, PK Melwani , P Purwar , A Kumar , CS Pramesh ,S Laskar , BN Pandey (# equal first authors)
A Kapoor, A Barai, B Thakur, A Das, Sejal R Patwardhan, M Monteiro, S Gaikwad, Amir B Bukhari, Pankaj Mogha, A Majumder, A De, P Ray, S Sen