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Research Projects

Molecular and functional characterization of small molecular inhibitor to evaluate antitumor activity in acute myeloid leukemia


The project is focused on the elucidation of alterations in signaling pathways leading to survival advantage and resistance to apoptosis in leukemic blast and develops innovative therapeutic approaches, with a focus on CDK7 inhibition and modulating redox homeostasis. Further, using in vitro, ex vivo and in vivo models of AML, we seeks to identify critical targets associated with Venetoclax/Cytarabine resistance and incorporate the novel targets in treatment regime to overcome the resistance.

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