Principal Investigator
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- Dr. Sharath C. Arandkar
Dr. Sharath C. Arandkar
Principal Investigator
Honors and Recognitions
- DBT Ramalingaswami Re-entry Fellowship, 2019
- PBC Fellowship for Outstanding Post-doctoral Researchers, Israel, 2014-2017
- EMBL Corporate Partnership Fellowship, EMBL, 2011
- DBT Travel Fellowship for attending the EMBO Conference, 2011
- IFCPAR/CEFIPRA travel grant for visit to Institute Genetique Moleculaire, Universite Paris 7, France, 2010
- Graduate Student Fellowship for pursuing Ph.D by Indian Institute of Science in 2007
- CSIR Fellowship 2007
Research Interests
- Tumor-microenvironment
- Cancer associated fibroblasts
- Fibrosis
- Tumor-Stroma interactions
- Immune-microenvironment
- TP53
RESEARCH
Main goal of our lab is to understand the “Biology of tumor-microenvironment (TME)”. During tumorigenesis tumor cells constantly interact with the surrounding microenvironment, which includes various stromal cell populations (fibroblasts, immune cells, Endothelial cells etc.) and ECM. Due to these bi-directional cross-talk, tumor cells convert the normal stroma to a pro-tumorigenic state. These stromal cells play a crucial role in tumor development and metastasis, we will specifically focus on understanding the multicellular complex cross-talk between tumor and stromal cell populations. Mainly, our lab is interested to explore the role of Cancer-Associated Fibroblasts (CAFs) in various cancers including pancreas, lung and breast etc. In addition, our lab will also further explore the immune microenvironment and its interactions with other stromal cell populations during tumor growth. We will use various cell and molecular biological methods including in-vitro co-culture organoids as well as in-vivo mouse xenograft models.
