The research involves miniaturized medical imaging equipments suitable for testing experimental concepts in small animal models, which can be directly translated into imaging-guided clinical applications to serve both cancer diagnosis and personalized therapy.
The lab is to take advantage of the preclinical imaging tools for understanding various aspects of the cellular processes; It is working on therapeutic evaluation of gene targeted radiotherapy and nanotherapeutics for breast and oral cancers.
The lab is developing optical imaging based tools for live monitoring of various cellular protein functions such as protein-protein interactions, protein phosphorylation and protease activation etc. Beside the research efforts we foster teaching and training of young researchers in these areas.
Among the various non-invasive tools, currently They are using imaging approaches involving positron emitting radioisotope based micro Positron Emission Tomography (microPET), X-ray diffraction based micro Computed Tomography (microCT) and visible range light signals based optical imaging (techniques based on bioluminescence and fluorescence). Biological molecules can be linked directly or indirectly to such signal emitting moieties/ molecules and there in vivo dynamics can be followed using one of these modalities suitable for capturing such signals.
Mal A, Dey P, Hayes RM, McCarthy JV, Ray A, De A (2020)
Rathod M, Kelkar M, Valvi S, Salve G, De A (2020)
Jain NK, Dimri S, Prasad R, Ravichandran G, De A, Srivastava R (2020)
Laxman K, Reddy BPK, Mishra SK, Gopal MB, Robinson A, De A, Srivastava R, Ravikanth M (2020)