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Principal Investigator

Dr. Ashok K Varma

Principal Investigator

Research Interests

  • Histone Biology and Cellular Plasticity
  • Chromatin Dynamics and DNA damage response
  • Epigenetics and Transcriptional Regulation
  • Chromatin Modifications and Resistance Mechanisms

RESEARCH

The lab will focus on the X-ray structure determination of biological macromolecules: proteins - nucleic acid. This detailed 3D visualization of proteins will brings to Structure Based Drug Design – Molecular Medicine- Treatment of Disease.

Ongoing Research Projects

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    BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…

  • project1

    IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…

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    FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex

  • project1

    ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…

  • project1

    Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…

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    CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis

  • project1

    MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…

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    EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Ashok K Varma

KS 101, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5112 avarma@actrec.gov.in Lab Website
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