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Principal Investigator

Dr. Sanjay Gupta

Principal Investigator

Research Interests

Epigenetics, Chromatin, DNA methylation, Transcriptional regulation and Molecular Carcinogenesis


"The lab is researching on: How cell cycle specific alteration in histones affects their role in DNA damage response; Clinical significance of alteration in covalent modification of histones in human cancers; Transcriptional regulation of histone variants, variant-specific PTMs and their binding partners during carcinogenesis; How structure and function of chromatin fibre is altered with the replacement of canonical histones by histone variants; How to translate this information into diagnostic and therapeutic tools for the better management of cancer."

Ongoing Research Projects

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    Histone Alterations and DNA Damage

    revious studies in different models from yeast to human cells imply that chromatin structure serves as a barrier… more

  • project1

    Histone PTM's and Cancer

    Epigenetic changes like histone post translational modifications and change in chromatin architecture are key ev… more

  • project1

    Histone Variants and Cancer

    "Histones are very highly conserved proteins and packaging the genome was the primary function previously associ… more

Lab Members



Office Contact

Dr. Sanjay Gupta

KS#313, Gupta Lab, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5086 Lab Website

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