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Principal Investigator

Dr. Sanjay Gupta

Principal Investigator

Research Interests

Epigenetics, Chromatin, DNA methylation, Transcriptional regulation and Molecular Carcinogenesis

RESEARCH

"The lab is researching on: How cell cycle specific alteration in histones affects their role in DNA damage response; Clinical significance of alteration in covalent modification of histones in human cancers; Transcriptional regulation of histone variants, variant-specific PTMs and their binding partners during carcinogenesis; How structure and function of chromatin fibre is altered with the replacement of canonical histones by histone variants; How to translate this information into diagnostic and therapeutic tools for the better management of cancer."

Ongoing Research Projects

  • project1

    Histone Alterations and DNA Damage

    revious studies in different models from yeast to human cells imply that chromatin structure serves as a barrier… more

  • project1

    Histone PTM's and Cancer

    Epigenetic changes like histone post translational modifications and change in chromatin architecture are key ev… more

  • project1

    Histone Variants and Cancer

    "Histones are very highly conserved proteins and packaging the genome was the primary function previously associ… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Sanjay Gupta

KS#313, Gupta Lab, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5086 sgupta@actrec.gov.in Lab Website

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