Principal Investigator
Recognized PhD Mentor for
Epigenetics, Chromatin, DNA methylation, Transcriptional regulation and Molecular Carcinogenesis
Histone proteins and their site-specific post-translational modifications regulate process like gene expression, DNA repair, and therefore emerging as key players in cancer and the resistance mechanisms. Recent advances from the group strongly indicate a role for histone, HIST2H2AC and H3.2, and also the part of 3’-UTR organization of histone genes for the genomic instability in human liver, gastric and breast cancers. Further, the critical role of chromatin modifiers like mitogen and stress activated kinase 1, protein phosphatase 1 and class 1 histone deacetylase for H3serine10phosphorylation along with site-specific acetylation in DNA damage response have been identified in human cell lines and gastric cancer tissues. Recent studies have shown reversible mechanism of resistance is mediated by changes in chromatin organization. These epigenetic regulators have significant clinical importance as they provide an opportunity for “epi-drugs” to reverse the specific marks for better management of cancer and resistance phenomena.
Previous studies in different models from yeast to human cells imply that chromatin structure serves as a barrie… more
Epigenetic changes like histone post translational modifications and change in chromatin architecture are key ev… more
Histones are very highly conserved proteins and packaging the genome was the primary function previously associa… more
The chromatin state is known to be influenced by multiple mechanisms, including changes in the histone PTMs, inc… more
Ph.D. student
Ph.D. student
Scientific Assistant F
Scientific Assistant F
Technician D
Technician D
PhD JRF
PhD JRF
PhD JRF
PhD JRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
PhD SRF
Natu A, Verma T, Khade B, Thorat R, Gera P, Dhara S, Gupta S (2024)
Gadewal N, Natu A, Sen S, Rauniyar S, Bastikar V, Gupta S (2024)
Pandya RK, Jijo A, Cheredath A, Uppangala S, Salian SR, Lakshmi VR, Kumar P, Kalthur G, Gupta S, Adiga SK (2023).