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Hematopoietic Stem Cell Transplantation (HSCT) is a procedure of infusing healthy blood forming stem cells into the patient’s body for treatment of several malignant (AML, ALL, CML, lymphoma, Multiple Myelomas) and non-malignant (SCID, Sickle cell disease, Thalassemia) complications. While HSCT is a life saving treatment, it is compromised by several endothelial complications such as Transplant associated- thrombotic microangiopathy (TA-TMA), Idiopathic pulmonary syndrome (IPS), Hepatic Veno-occlusive disease (HVOD), Engraftment syndrome.

Approximately 40% children with cancer are malnourished at diagnosis. Malnutrition in young children with cancer can be a result of poor dietary intake or due to cachexia induced by cancer itself. In cancer, malnutrition is often associated with adverse outcomes in terms of safety, tolerability an efficacy of drugs. The effect could be mediated either through an inherent vulnerability of a child with malnutrition to the toxicity of chemotherapy, thereby affecting dose intensity and loos of efficacy.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and contributes 85% of all lung cancers. Mitochondria play a vital role in cell survival and are also the primary source of ROS generation that regulates the cellular redox homeostasis. However, excess production of ROS can trigger apoptotic cell death. Hence, targeting mitochondria can be a good strategy for killing cancer cells. The dedicated thioredoxin and glutathione redox systems are the central antioxidant defense mechanisms by which mitochondria neutralize the excess ROS.

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumour. Challenges associated with therapeutic modalities involve the diffusion constraints of the blood-brain barrier (BBB). Limitations associated with conventional treatment necessitate the development of alternative approaches for radiotherapy adjuvant drugs. Selenium functionalised gold nanocomposites were synthesised and optmised.

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