aims to identify the role of AP-1 (Activator protein-1) subunit complex and its related genes, in aiding metastasis under the effect of hypoxic pressures during surgical resection. We will be using a variety of knockdown and overexpression assays in invitro both cell line as well as in-vivo animal models to investigate the role of AP-1 in metastatic spread of cancer.
is a flagship study funded by the Department of Biotechnology, Government of India. This is a multi-institutional study between The Tata Memorial Centre (TMH & ACTREC), The National Institute of Biomedical Genomics (NIBMG), Kalyani and National Centre for Cell Sciences (NCCS), Pune. The VNCI study aims using a variety of multi-omics big data technologies comprehensive characterization of endocrine hormone therapy resistant and sensitive breast cancer tumours, in hormone receptor positive, HER2 -ve breast cancer patients.
funded by the Tata Memorial Centre, aims to investigate the utility of a liquid biopsy using cell free DNA (cfDNA) for monitoring response of breast cancer patients to therapy in the neo-adjuvant chemotherapy (NACT) settings. We have biopsied patients undergoing neo-adjuvant chemotherapy before the start of their therapy, and at the time of their surgical resection. We have also collected patients’ blood before every cycle of chemotherapy and isolated cfDNA from the plasma.
is funded by the Department of Science and Technology, Government of India. Triple Negative Breast Cancer (TNBC) is a type of breast cancer characterized by the lack of expression of hormone receptors. TNBC is an aggressive breast cancer, very often irresponsive to treatment. Moreover, TNBC has more propensity to metastasize to other organs.
funded by the Tata Memorial Centre explores the role of peri-operative hypoxia in breast cancer biology. Hypoxia is a consistent feature of most solid tumours with variable incidence and severity. Chronic hypoxia has been well studied and characterized. However, the role of acute hypoxia, especially in the peri-operative setting wherein ligation of blood vessels leads to acute hypoxia in surgically resected tissue, requires elucidation.
The proluton study aimed to identify the molecular mediators of beneficiary survival effect of a single depot hydroxyl-progesterone dose in node positive patients eligible for upfront surgical resection (PMID: 21670457). We subjected patient samples before, and after, hydroxyl-progesterone peri-operative intervention, to whole transcriptome sequencing on a next generation sequencing platform.