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Pre-clinical investigation of nutritional interventions to reverse the higher susceptibility to chemotherapy-related toxicity caused by moderate malnutrition


Approximately 40% children with cancer are malnourished at diagnosis. Malnutrition in young children with cancer can be a result of poor dietary intake or due to cachexia induced by cancer itself. In cancer, malnutrition is often associated with adverse outcomes in terms of safety, tolerability an efficacy of drugs. The effect could be mediated either through an inherent vulnerability of a child with malnutrition to the toxicity of chemotherapy, thereby affecting dose intensity and loos of efficacy. Alternatively, malnourishment may alter the pharmacokinetics of chemotherapeutic drugs leading to higher exposures and subsequent toxicity. Hence, with the aid of a sprinkler formulation containing all the micronutrients and macronutrients we aim to replenish the nutrients, which in turn, may improve the pharmacokinetics of the chemotherapeutic drugs leading to less or no adverse effects

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