Principal Investigator

Dr. Ashok K Varma

Research Interests

Histone Biology and Cellular Plasticity
Chromatin Dynamics and DNA damage response
Epigenetics and Transcriptional Regulation
Chromatin Modifications and Resistance Mechanisms

RESEARCH

The lab will focus on the X-ray structure determination of biological macromolecules: proteins - nucleic acid. This detailed 3D visualization of proteins will brings to Structure Based Drug Design – Molecular Medicine- Treatment of Disease.

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…
IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…
FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex
ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…
Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…
CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis
MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…
EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

Vaishnvee Chikhale
Junior Research Fellow
Vaishnvee Chikhale
Junior Research Fellow
R N Sawant
Technician
R N Sawant
Technician
Suchita Dubey
Senior Research Fellow
Suchita Dubey
Senior Research Fellow
Mudassar Ali Khan
Senior Research Fellow
Mudassar Ali Khan
Senior Research Fellow
Nabajyoti Goswami
Principal Project Associate
Nabajyoti Goswami
Principal Project Associate
Dr. Reshita Barua
Project Scientist
Dr. Reshita Barua
Project Scientist
Ulka U Sawant
Scientific Assistant
Ulka U Sawant
Scientific Assistant
Neha Mishra
Senior Research Fellow
Neha Mishra
Senior Research Fellow
Siddhartha Barua
Senior Research Fellow
Siddhartha Barua
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow

Alumni

Lipi Das
RA in Mizoram University

PUBLICATIONS

2022
Breast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast India; Natl J Community Med 2022;13(9):606-611
Doris Zodinpuii, Jeremy L Pautu, Bawitlung Zothankima, Lalfakzuala Khenglawt, Doris Lallawmzuali, Rebecca Lalmuanpuii, Lalfak zuali, Lalengkimi Ralte, Rajendra B Muthukumaran, Ashok K Varma, John Zothanzama, Nachimuthu Senthil Kumar
In-silico and structure-based assessment to classify VUS identified in the α-helical domain of BRCA2, Journal of Biomolecular Structure and Dynamics, (2022): DOI: 10.1080/07391102.2022.2148127
Mudassar Ali Khan & Ashok K Varma
Evaluation of conformational transitions of h-BRCA2 functional domain and unclassified variant Arg2502Cys using multimodal approach. International Journal of Biological Macromolecules. Macromolecules. 209: Part A:716-724
Khan MA, Siddiqui MQ, Kuligina E, Varma AK
Multimodal approach to characterize the tetrameric form of human PML-RBCC domain and ATO-mediated conformational changes, Int J Biol Macromol, (2022), 223 468–478
Suchita Dubey, Neha Mishra, Nabajyoti Goswami ,M. Quadir Siddiqui, Ashok K.Varma

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Contact

Office Contact

Dr. Ashok K Varma

KS 101, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5112 avarma@actrec.gov.in Lab Website

Principal Investigator

Lab Website

Dr. Ashok K Varma

Research Interests

RESEARCH

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…

IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…

FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex

ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…

Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…

CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis

MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…

EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

Alumni

Lipi Das

PUBLICATIONS

Contact

Office Contact

Dr. Ashok K Varma

For Research Scientist

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