Highlights of the research findings at Bose Lab include elucidation of the structural basis of HtrA2 mutations that are implicated in diseased phenotypes. Crystallography data of one such mutants has been deposited in Protein Data Bank (PDB ID: 5WYN). The laboratory has made several important discoveries such as mode of interaction of HtrA2 with its natural substrate, identification of a novel binding partner as well as design of its promising inhibitors. These crucial pieces of information would provide means to manipulate HtrA2 with desired characteristics. The laboratory has developed a database comprising PDZ-domain containing proteins ‘PDZscape’, which is freely available to the users worldwide.
The project involves understanding allosteric behavior of a proapoptotic serine protease HtrA2 so as to establis… more
With the information that Fas-mediated apoptosis and tumorigenesis are influenced by CaM/c-FLIP With the informa… more
This project aims at elucidating GRIM-19-mediated allosteric activation of HtrA2 with an aim at designingThis pr… more
This project concerns design, synthesis & profiling of specific HtrA2/Omi inhibitor that might be useful for… more
Scientific Officer 'F' and Principal Investigator
Scientific Assistant 'C'
Bose K, Wagh A, Mishra V, Dutta S, Parui A, Puja R, Pandav-Mudrale S, Kulkarni S, Gai P, Sarin R (2021)
Kummari R, Dutta S, Patil S, Pandav-Mudrale S, Bose K (2021)