Principal Investigator
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- Dr. Kakoli Bose
Dr. Kakoli Bose
Principal Investigator
Honors and Recognitions
- Recipient of National Women Bioscientist Award, Govt. of India, 2015 (Young Category)
- Editorial Board Member, Biochem. J, Portland Press, UK.
Research Interests
- Biophysics, Biochemistry, Structural Biology, ChemicalBiology, Cell Biology, Enzymology and Computational Biology
- Research focused on macromolecules involved in alternate pathways of apoptosis and their associated diseases
RESEARCH
Highlights of the research findings at Bose Lab include elucidation of the structural basis of HtrA2 mutations that are implicated in diseased phenotypes. Crystallography data of one such mutants has been deposited in Protein Data Bank (PDB ID: 5WYN). The laboratory has made several important discoveries such as mode of interaction of HtrA2 with its natural substrate, identification of a novel binding partner as well as design of its promising inhibitors. These crucial pieces of information would provide means to manipulate HtrA2 with desired characteristics. The laboratory has developed a database comprising PDZ-domain containing proteins ‘PDZscape’, which is freely available to the users worldwide.
