Clinician

RESEARCH

The primary focus of clinician scientist laboratory (CSL) is on understanding the biological role of hypoxia in cancer metastasis & cancer spread, clonal evolution of a tumour leading to therapy resistance, and developing novel blood based assays to monitor tumour burden and response to therapy. Our laboratory comprises of an interdisciplinary group of surgical oncologists, medical oncologists, pathologists, basic scientists, and data scientists collaborating on addressing questions formulated from clinical observations. Our laboratory uses a bedside - to bench - to bedside approach where-in observations from the clinics generate a hypothesis. We then test this hypothesis using pre-clinical assays. Big data generated from patient samples using OMICS technologies integrate with, and inform, these pre-clinical assays. We use a variety of model systems including in-vitro cell-based assays, in-vivo animal studies and 3D organoid cultures to address our research questions. The eventual goal of our laboratory is to translate our pre-clinical findings in the laboratory into relevant interventions addressing clinical problems. Our laboratory is the nodal laboratory for the multi-omics endocrine hormone resistance study in breast cancer initiative under the aegis of the Virtual National Cancer Institute (VNCI) endeavor by the Department of Biotechnology, Govt. of India.