Protein synthesis (translation) is an essential process and is tightly coordinated with the cellular environment. Our research group in ACTREC is interested in exploring the novel mechanisms of regulation of protein synthesis under various growth and disease conditions. We employ both yeast and cancer cells as model systems to understand the regulation of protein synthesis by signaling pathways such as mTOR. We will explore various post-translational modifications of translation factors and mRNA binding proteins and ribosome composition in the regulation of protein synthesis. In addition, cells may utilize non-canonical protein synthesis mechanisms under stress conditions to produce proteins that may help in their survival. Hence, we are interested in identifying such proteins synthesized by non-canonical mechanisms and investigating their role in cancer cells. If our research questions interest you and you would like to work or collaborate with us, do write to us!
Shetty S, Hofstetter J, Battaglioni S, Ritz D, and Hall MN
Shimobayashi M, Thomas A, Shetty S, Frei IC, et al.,
Shetty S, and Hall MN