Principal Investigator
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- Dr. Sunil Shetty
Dr. Sunil Shetty
Principal Investigator
Honors and Recognitions
- Assistant Professor, Homi Bhabha National Institute (HBNI), Mumbai – 2023
- Research funding from Jubilaumsstiftung von Swiss Life, Switzerland – 2022
- Indian National Science Academy (INSA) Young Scientist Award – 2017
- M. Sreenivasaya Medal for Best PhD thesis by IISc, Bangalore for 2016 – 2017
- Long Term Postdoctoral Fellowship, EMBO, Heidelberg – 2016
- Shyama Prasad Mukherjee Fellowship, CSIR – 2010
Research Interests
- Regulation of protein synthesis by signaling pathways
- Alternative translation mechanisms during the stress response
- mTOR signaling and its role in mRNA metabolism
RESEARCH
Protein synthesis (translation) is an essential process and is tightly coordinated with the cellular environment. Our research group in ACTREC is interested in exploring the novel mechanisms of regulation of protein synthesis under various growth and disease conditions. We employ both yeast and cancer cells as model systems to understand the regulation of protein synthesis by signaling pathways such as mTOR. We explore various post-translational modifications of translation factors and mRNA binding proteins and ribosome composition in the regulation of protein synthesis. In addition, we are also interested in understanding non-canonical protein synthesis mechanisms under stress conditions. We investigate peptides/proteins synthesized by non-canonical mechanisms and examine their role in cancer cells. If our research questions interest you and you want to work or collaborate with us, write to us!
