Secretory phospholipase A2 group-IIA (sPLA2-IIA) catalyzes the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. sPLA2-IIA is deregulated in various human cancers. Findings from this laboratory are that sPLA2-IIA knockdown in oral cancer cell lines showed decreased tumorigenic potential through c-Jun/JNK activation. Similarly, sPLA2-IIA knockdown in breast cancer cells and breast cancer stem cells (BCSCs) also showed decreased tumorigenic and metastatic potential.