Our research has demonstrated that the initiation of desmosome formation is dependent on the plaque protein, plakophilin3, in human cells. Loss of plakophilin3 leads to increased neoplastic progression and metastasis and our work has identified molecular determinants downstream of plakophilin3 loss that are important for tumor progression and metastasis. Studying the mechanisms by which cell-cell interactions are generated and dissolved will lead to an understanding of the molecular mechanisms by which these processes are regulated and may lead to the development of novel therapeutic strategies for treating neoplastic disease.
Another area of focus in the laboratory is to elucidate the mechanisms by which the 14-3-3 protein family regulates different cellular processes. As part of these studies we have determined the molecular basis for specific complex formation between 14-3-3 proteins and the cdc25C protein phosphatase.
The lab has also focused on devising novel technologies for the generation of transgenic mice that either over-express or have a knockdown of specific gene products.
The desmosome is an adherens like junction that is present in all epithelial tissues and is especially abundant… more
Plakophilin3 (PKP3) is a desmosomal plaque protein that is required for desmosome formation and whose levels are… more
The purpose of the eukaryotic cell cycle is to accurately duplicate and segregate the genome. Progression throug… more
Work in the laboratory has led to the development of a novel method for the generation of transgenic animals. US… more
14-3-3σ is expressed only in cells of epithelial origin and loss of 14-3-3σ has been observed in multiple solid… more
Senior Research Fellow
Bose A, Dalal SN
Vishal SS, Tilwani S, Dalal SN
Basu S, Chaudhary N, Shah S, Braggs C, Sawant A, Vaz S, Thorat R, Gupta S, Dalal SN