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Principal Investigator

Dr. Sorab Dalal

Principal Investigator

Research Interests

  • Regulation of desmosome formation.
  • Therapy resistance in colon cancer
  • Regulation of cell cycle control and other cellular pathways by 14-3-3 proteins.

 

RESEARCH

Our research has demonstrated that the initiation of desmosome formation is dependent on the plaque protein, plakophilin3, in human cells. Loss of plakophilin3 leads to increased neoplastic progression and metastasis and our work has identified molecular determinants downstream of plakophilin3 loss that are important for tumor progression and metastasis. Studying the mechanisms by which cell-cell interactions are generated and dissolved will lead to an understanding of the molecular mechanisms by which these processes are regulated and may lead to the development of novel therapeutic strategies for treating neoplastic disease.

Another area of focus in the laboratory is to elucidate the mechanisms by which the 14-3-3 protein family regulates different cellular processes. As part of these studies we have determined the molecular basis for specific complex formation between 14-3-3 proteins and the cdc25C protein phosphatase.

The lab has also focused on devising novel technologies for the generation of transgenic mice that either over-express or have a knockdown of specific gene products.

Ongoing Research Projects

  •  Regulation of desmosome assembly

    REGULATION OF DESMOSOME FORMATION

    The desmosome is an adherens like junction that is present in all epithelial tissues and is especially abundant… more

  • Regulation of tumor progression by 14-3-3 proteins

    PLAKOPHILIN3 FUNCTIONS REQUIRED FOR THE INHIBITION OF TUMOR PROGRESSION AND METAST…

    Plakophilin3 (PKP3) is a desmosomal plaque protein that is required for desmosome formation and whose levels are… more

  • Cell cycle and 14-3-3

    REGULATION OF CELL CYCLE CONTROL AND CHECKPOINT FUNCTION BY 14-3-3 PROTEINS

    The purpose of the eukaryotic cell cycle is to accurately duplicate and segregate the genome. Progression throug… more

  • Tissue organization and regulation by 14-3-3

    REGULATION OF TISSUE ORGANIZATION AND DIFFERENTIATION BY 14-3-3 PROTEINS

    Work in the laboratory has led to the development of a novel method for the generation of transgenic animals. US… more

  • tumor progression and 14-3-3

    REGULATION OF TUMOR PROGRESSION BY 14-3-3 PROTEINS

    14-3-3σ is expressed only in cells of epithelial origin and loss of 14-3-3σ has been observed in multiple solid… more

Lab Members

Alumni

PUBLICATIONS

Contact

Office Contact

Dr. Sorab Dalal

Sorab’s Laboratory KS 230, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India. +91 (022) 2740 5000/ 6873 5000 Extn-5007Lab Website

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