Principal Investigator
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- Dr. Shilpee Dutt
Dr. Shilpee Dutt
Principal Investigator
Research Interests
Therapy resistance in cancer, DNA damage and repair, epigeneitcs, glioblastoma, leukemia
Achievements / Awards / Honors:
- Recipient of Janaki Ammal-National Women Bioscientist Award (Young Category) by
Department of Biotechnology, Government of India 2019 - Recipient of President’s Award for the Outstanding Work in Neuro-Oncology by Indian
Society of Neuro-Oncology (ISNO) 2017 - Recipient of Dr. Virendra Balkrishna Kamat Award by Indian Association of Cancer Research
(IACR) 2016 - Platform presentation at American Association of Hematology (ASH) 2009
- Recipient of Prestigious Swiss National Science Foundation Postdoctoral Fellowship 2005
- Best Oral Presentation Award, University of Zurich 2004
- Travel Award by Society for Neuroscience USA 2003
- Best Oral Presentation Award, The Connective Tissue Society, Ulm, Germany 2002
- CSIR JRF- NET fellowship in life sciences 1998
- UGC JRF- NET fellowship in life sciences 1998
- First Position in B.Sc, University of Delhi 1996
RESEARCH
Our laboratory is interested in understanding the molecular mechanisms of resistance, the most germane and fundamental issue in the cancer therapeutics with a particular focus on DNA repair pathways and their epigenetic regulation. We take the multi-pronged approach employing molecular biology, cell biology, genomics and proteomics to answer some of the basic questions pertaining to chemo and radiation resistance. Using clinically relevant patient samples and patient-derived cellular and mouse models developed in our lab, we have identified novel and targetable molecular pathways employed by leukemic and glioblastoma cells to acquire resistance and relapse. We collaborate with the clinicians at ACTREC and TMH to translate the basic research findings into clinics.
