Our group has long drawn interest in Cancer Nanomedicines which provide alternative treatment solutions for otherwise difficult to treat cancers. To develop various bio-functionalized, tumor-targeted nanomedicine materials for cancer therapy, we are actively engaged in multiple collaborative projects. In one promising line of work done in collaboration with NanoBios Lab at IlT-B, we have tested multiple biocompatible gold-nanospheres (Au-NS) nanomaterial for photothermal therapy (PTT). This method shows exceptional therapy efficacy in vivo. This triggered, precisive treatment method of palpable solid tumors with accumulated nano-sized particles when briefly exposed to NIR laser irradiation confers excellent tumor tissue ablation, while keeping the surrounding tissue safe ACS Nanoletters, 2015; Scientific Reports, 2018; Applied Materials Today. 2020; Nanomedicine: Nanotechnology, Biology, and Medicine 2021: Nanoscale 2022]. This mode of treatment is found to be fast, portable and could be a cost-effective procedure tested against human drug- resistant and radiation-resistant human cancers of multiple types using preclinical mouse models and non-invasive imaging [Biomaterials Advances, 2022] Additionally, we have completed work validating two novel organic NIR dyes with exceptional photothermal effect and published in high impact nternational iournals [ACS Appl. Mater. Interfaces, 2020: NPG Asi= Materials, 2020]. We were granted with multiple patents on this line of work. Working with Chemistry dept. NMIMS Mumbai very recently we have also reported synthesis of a multifunctional CuS-ZnS nanocomposites modified in situ for targeted cancer therapy and imaging. Here the Cus moiety anabled near-infrared light responsive photothermal therapy heress ZnS showed potential for photoluminescence [Journal of Drug Delivery Science and Technology 2022