The effective management of critically ill patients in Intensive Care Units (ICUs) heavily relies on the precise monitoring of drug levels. Traditional laboratory methods for drug level measurement often involve time-consuming processes, hindering timely intervention. To address this gap, this prospective study aimed to develop and validate point-of-care devices tailored for measuring commonly used drugs in ICUs. Leveraging innovative technologies and analytical methodologies, a comprehensive approach of electrochemical technique are employed to design and optimize these devices for accuracy, reliability, and user-friendliness. The validation process encompassed rigorous testing against gold-standard laboratory techniques, ensuring robust performance across a range of clinical scenarios. Additionally, usability assessments will be conducted to evaluate practical implementation and acceptance among healthcare professionals. Thus, it will highlight the feasibility and potential of these point-of-care devices to revolutionize drug monitoring practices in ICUs, offering real-time insights and enabling personalized therapeutic interventions, ultimately improving patient outcomes and healthcare efficiency.