Prognostic & predictive roles of cancer stem cell markers in HNSCC patients
Recent publication in the British Journal of Cancer by Dr Manoj Mahimkar’s group at ACTREC proposed potential predictive biomarkers for stratifying head and neck squamous cell carcinoma (HNSCC) patients for epidermal growth factor receptor (EGFR)-targeted therapy based treatments. HNSCC are a heterogeneous group of cancers and a leading cause of mortality in India. . Treatment modalities for HNSCC are decided based on the stage of the disease. However, patients respond differently to each treatment and not all patients receive benefits...
Red seaweed polysaccharide derived nanocomposites help fight cancer
The researchers, led by Dr Jyoti Kode at the Advanced Centre for Treatment, Research & Education in Cancer, Tata Memorial Centre in Navi Mumbai, India, found that the nanocomposite controlled the growth of human colon, blood and breast cancer cells. The nanocomposite, made using red seaweed-derived polysaccharide and silver nanoparticles, has been found to selectively kill the cancer cells, sparing healthy cells. These findings, the researchers say, show the potential applications of abundant, renewable seaweed biomass in developing cancer nanotherapy...
Randomised trial comparing pelvic radiotherapy to prostate-only...
Radical radiotherapy to the prostate is the recommended curative treatment for ‘high risk’ prostate cancer which is localised to the prostate, but with increased risk of involvement of pelvic lymph nodes. Yet, the benefit of radiotherapy to the whole pelvis has not been established. Randomised trial of Prostate Only or Pelvic Radiotherapy in high risk prostate cancer (POP-RT) from Tata Memorial Centre is comparing the benefit of radiotherapy to pelvic nodes in addition to prostate, using modern conformal
technique of image guided intensity modulated radiotherapy (IG-IMRT)...
Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence
Recently Dr. Shilpee Dutt’s lab at ACTREC published important manuscripts in ‘Cancer Letter’ that address the fundamental issue of radiation resistance and recurrence in glioblastoma multiforme (GBM). GBM is the most aggressive and malignant primary brain tumor with median overall survival of barely 18 months. Despite multimodal therapy recurrence in GBM is inevitable making GBM the most difficult brain tumor to treat. GBM recurrence is due to the residual disease cells that are left after surgery and radio-therapy. Therefore, it is imperative to eliminate ...
Inhibition of SETMAR-H3K36me2-NHEJ repair axis in residual disease cells prevent glioblastoma
Recently Dr. Shilpee Dutt’s lab at ACTREC published important manuscripts in ‘Neuro-Oncology’ that address the fundamental issue of radiation resistance and recurrence in glioblastoma multiforme (GBM). GBM is the most aggressive and malignant primary brain tumor with median overall survival of barely 18 months. Despite multimodal therapy recurrence in GBM is inevitable making GBM the most difficult brain tumor to treat. GBM recurrence is due to the residual disease cells that are left after surgery and radio-therapy. Therefore, it is imperative to eliminate ...