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Scientific Officer

Dr Syed K. Hasan

Scientific Officer E

Honors and Recognitions

  • Travel grant from Society of Hematologic Oncology, Houston, USA 2018
  • European Hematology Partner Fellowship, Netherlands (2012-2014)
  • Ramalingaswami grant by DBT, Govt of India 2011
  • Pre-doctoral Fellowship, University of Rome Tor Vergata, Italy (2006-2009

Research Interests

  • Understanding the signalling between anti-apoptotic proteins and cyclin dependent kinases in Acute Myeloid Leukemia (AML) and Breast cancer.
  • Functional and molecular aspects of novel agents in leukemia, AML xenografts models
  •  Molecular characterization of high risk Acute Promyelocytic Leukemia

     

RESEARCH

The major focus of our lab is to understand the signaling between anti-apoptotic proteins and cyclin dependent kinases and combining their targeted actions for the improved therapeutic strategies to overcome apoptotic resistance in leukemia. Our lab is collaborating with a biotech based organization – Aurigene Drug Discovery and Development Technologies Bangalore and Prof Marina Konopleva at MD Anderson Cancer Centre, Houston to address the targeted approaches in leukemia. Monitoring of minimal residual disease (MRD) by molecular markers, identification of miRNA-mRNA network in AML and characterization of high-risk acute promyelocytic leukemia are other research aspects of the laboratory.

Ongoing Research Projects

  • project1

    Molecular and functional characterization of small molecule inhibitors to evaluate…

    The survival of acute myeloid leukemia (AML) blasts is dependent on the mitochondrial ap… more

  • project1

    Genetic and functional characterization of high risk acute promyelocytic leukemia

    With the advent of targeted therapy using arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) very high cu… more

  • project1

    Evaluation of in vitro effects of novel small molecule inhibitors on primary patie…

    Cyclin-dependent kinases (CDKs) regulate cell cycle and cell proliferation. CDK inhibition is predominantly succ… more

  • project1

    Multidisciplinary approach to evaluate the pathogenicity of missense mutations ca…

    more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr Syed K. Hasan

KS 244, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India. +91 (022) 2740 5000/ 6873 5000 Extn-5148 shasan@actrec.gov.in Lab Website
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