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Principal Investigator

Dr. Sanjeev Waghmare

Principal Investigator

RESEARCH

The focus of our group is to unravel the molecular and cellular mechanisms involved in the developmental signaling such as Wnt/Notch/Sonic hedgehog etc., and metabolic pathways that regulate the self-renewal and differentiation of adult stem cells and cancer stem-like cells including its therapy resistance to epithelial cancer. We are using transgenic animal skin epithelia model, head and neck cancer, and also have developed patient-derived oral cancer cell lines, to identify the genes involved in signaling pathway and metabolic switch that imparts resistance to cancer stem cells thereby providing avenues for therapeutic intervention.

Ongoing Research Projects

  • project1

    Role of Phospholipase A2/EF in epidermal stem cell regulation in mice

    Enhancing factor (EF), a growth factor modulator, is the mouse homologue of human secretory group II phospholipa… more

  • project1

    Delineating the molecular signalling mechanism in epidermal stem cell regulation a…

    Signaling pathways such as Wnt/Notch/Sonic hedgehog regulate stem-cell renewal, and genes affected in these path… more

  • project1

    Defining the novel tumor-initiating cells from human breast cancer

    Breast cancer is classified into four subtypes in clinic as ER+ (luminal A or luminal B, usually PR+/− Her2−),ov… more

  • project1

    Defining the role of signalling pathways in Head and Neck Cancer stem cells

    "Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for cancer-related mortality. Research in c… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Sanjeev Waghmare

Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India. +91 (022) 2740 5000/ 6873 5000 Extn-5122 swaghmare@actrec.gov.in Lab Website

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