Dab2 (Disabled-2 protein) is an adaptor protein and acts as a Wnt inhibitor. This group's finding showed that Dab2 knockout mice showed decreased cell proliferation and stem cells lost their stemness potential. Further, skin-induced tumors using DMBA/TPA application in the Dab2 knock-out skin showed decreased proliferation of the cells, and also, the tumors do not progress into squamous cell carcinoma.