Collaborative study with Prof Hebert, nutritional epidemiologist-(Univ. South Carolina) & leading Indian cancer epidemiolgist Dr Prakash Gupta (Healis Institute for Public Health, Mumbai) and future plans for pooling of data on additional analyses with the Breast Cancer Association Consortium – BCAC (Prof. Douglas Easton, Cambridge) & Consortium of Investigators of Modifiers of BRCA1/2 – CIMBA ( Dr. Chenevix-Trench, Australia).

It is now the Apex National Referral Centre for comprehensive clinical and laboratory genetic services and genetics research for all major cancer predisposition syndromes and a model of Comprehensive Cancer Genetics Unit (dedicated daily Genetics Clinic plus Genetics Lab). Best international practices in counselling, genetic testing, screening & medical management developed and tailored for Psycho-Social-Cultural dynamics unique to Indian families.

This international collaborative project aims to establish a comprehensive catalogue of Genomic & other abnormalities in 500 tumours each of 50 different Cancer types of Clinical & Societal importance across the globe. India has taken up Comprehensive Genomic and associated analyses of the most prevalent Indian Cancer – Gingivo-Buccal Squamus Carcinoma. All the 500 cases will be accrued in ACTREC, deep resequencing at NIBMG and associated methylation, transcriptome, IHC and functional analyses will be done at ACTREC.

Established a major programme under International Cancer Genome Consortium – India projectwhere high quality annotated tumour specimens are being banked. Deep resequencing of oral cancer initiated at NIBMG & associated analysis at ACTREC. This approach will be extended to other paired benign – cancer specimens for step wise carcinogenesis