Dynamic modulation of key kinases govern development of chemo resistance through multiple mechanisms. Currently we are interested in understanding how MAPK/ERK and PI3K/AKT signalling fine tune autophagic flux to promote development of platinum-taxol dual resistance. Further we are developing state of art optical sensors for real time non-invasive imaging of these key signalling pathways in order to delineate and implement an optimal therapeutic strategy at precise therapeutic window to combat chemo resistance.

For epithelial ovarian cancer (EOC), the incidence of relapse is overwhelming and is attributed to acquired chemo resistance. Patients that present with distant metastases at relapse show poor prognosis as the disease is often incurable. Previous studies from our lab have shown that IGF1R signalling, which is known to control chemo resistance and metastasis independently, shows oscillatory pattern across sensitive, early and late chemo-resistant EOC cells.